Title:
INTRANASAL ADMINISTRATION OF ACTIVE AGENTS TO THE CENTRAL NERVOUS SYSTEM
Document Type and Number:
WIPO Patent Application WO2006091332
Kind Code:
A3
Abstract:
A method for delivering a polypeptide to the central nervous system of a mammal is provided. The method involves attaching the polypeptide to an antibody or an antibody fragment and administering the fusion polypeptide intranasally, for delivery to the central nervous system. Methods of treatment are also provided, where a therapeutically effective amount of the composition is delivered to the nasal cavity of a mammal.
Inventors:
BENTZ HANNE (US)
HILL BETH (US)
LUCAS CATHERINE (US)
FREY WILLIAM H (US)
HILL BETH (US)
LUCAS CATHERINE (US)
FREY WILLIAM H (US)
Application Number:
PCT/US2006/003110
Publication Date:
November 16, 2006
Filing Date:
January 27, 2006
Export Citation:
Assignee:
ALZA CORP (US)
BENTZ HANNE (US)
HILL BETH (US)
LUCAS CATHERINE (US)
FREY WILLIAM H (US)
BENTZ HANNE (US)
HILL BETH (US)
LUCAS CATHERINE (US)
FREY WILLIAM H (US)
International Classes:
A61K38/00; A61K38/34; A61K39/395; A61K47/48; A61P3/04
Domestic Patent References:
| WO2000033813A1 | 2000-06-15 |
Other References:
FEHM HORST L ET AL: "The melanocortin melanocyte-stimulating hormone/adrenocorticotropin4 10 decreases body fat in humans", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 86, no. 3, March 2001 (2001-03-01), pages 1144 - 1148, XP002397602, ISSN: 0021-972X
HALLSCHMID M ET AL: "Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man", PHYSIOLOGY AND BEHAVIOR, ELSEVIER SCIENCE LTD., OXFORD, GB, vol. 83, no. 1, 30 October 2004 (2004-10-30), pages 55 - 64, XP004610706, ISSN: 0031-9384
FREY II W H ET AL: "Delivery of <125>I-NGF to the brain via the olfactory route", DRUG DELIVERY: JOURNAL OF DELIVERY AND TARGETING OF THERAPEUTIC AGENTS 1997 UNITED STATES, vol. 4, no. 2, 1997, pages 87 - 92, XP009071834, ISSN: 1071-7544
ROSS T M ET AL: "Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: A non-invasive treatment strategy for multiple sclerosis", JOURNAL OF NEUROIMMUNOLOGY 2004 NETHERLANDS, vol. 151, no. 1-2, 2004, pages 66 - 77, XP002397603, ISSN: 0165-5728
BAI X -F ET AL: "Complexities of applying nasal tolerance induction as a therapy for ongoing relapsing experimental autoimmune encephalomyelitis (EAE) in DA rats", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 111, no. 1, January 1998 (1998-01-01), pages 205 - 210, XP002397604, ISSN: 0009-9104
CORNFORD E M ET AL: "New systems for delivery of drugs to the brain in neurological disease", LANCET NEUROLOGY, LANCET PUBLISHING GROUP, LONDON, GB, vol. 1, no. 5, September 2002 (2002-09-01), pages 306 - 315, XP004811298, ISSN: 1474-4422
ILLUM LISBETH: "Is nose-to-brain transport of drugs in man a reality?", THE JOURNAL OF PHARMACY AND PHARMACOLOGY. JAN 2004, vol. 56, no. 1, January 2004 (2004-01-01), pages 3 - 17, XP009071639, ISSN: 0022-3573
HALLSCHMID M ET AL: "Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man", PHYSIOLOGY AND BEHAVIOR, ELSEVIER SCIENCE LTD., OXFORD, GB, vol. 83, no. 1, 30 October 2004 (2004-10-30), pages 55 - 64, XP004610706, ISSN: 0031-9384
FREY II W H ET AL: "Delivery of <125>I-NGF to the brain via the olfactory route", DRUG DELIVERY: JOURNAL OF DELIVERY AND TARGETING OF THERAPEUTIC AGENTS 1997 UNITED STATES, vol. 4, no. 2, 1997, pages 87 - 92, XP009071834, ISSN: 1071-7544
ROSS T M ET AL: "Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: A non-invasive treatment strategy for multiple sclerosis", JOURNAL OF NEUROIMMUNOLOGY 2004 NETHERLANDS, vol. 151, no. 1-2, 2004, pages 66 - 77, XP002397603, ISSN: 0165-5728
BAI X -F ET AL: "Complexities of applying nasal tolerance induction as a therapy for ongoing relapsing experimental autoimmune encephalomyelitis (EAE) in DA rats", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 111, no. 1, January 1998 (1998-01-01), pages 205 - 210, XP002397604, ISSN: 0009-9104
CORNFORD E M ET AL: "New systems for delivery of drugs to the brain in neurological disease", LANCET NEUROLOGY, LANCET PUBLISHING GROUP, LONDON, GB, vol. 1, no. 5, September 2002 (2002-09-01), pages 306 - 315, XP004811298, ISSN: 1474-4422
ILLUM LISBETH: "Is nose-to-brain transport of drugs in man a reality?", THE JOURNAL OF PHARMACY AND PHARMACOLOGY. JAN 2004, vol. 56, no. 1, January 2004 (2004-01-01), pages 3 - 17, XP009071639, ISSN: 0022-3573
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