INTRAORAL FILM-LIKE BASE AGENT AND FORMULATION

Title:

INTRAORAL FILM-LIKE BASE AGENT AND FORMULATION

Document Type and Number:

WIPO Patent Application WO/2010/087032

Kind Code:

A1

Abstract:

Disclosed is a film-like base wherein one or more sugars or sugar alcohols are dispersed as microparticles is prepared by dispersing edible polymer, which is soluble in water and organic solvent with solubility parameter of 9.7 or greater, and one or more particles with mean particles size of 0.1-60 µm, which are selected from a group of monosaccharides - hexasaccharides and sugar alcohols thereof that are insoluble in organic solvent in said organic solvent. A drug is then included to prepare a film-like preparation. Provided as a result are an oral film-like base and preparation that have a fast dissolution profile in the mouth and sufficient film strength and have reduced stickiness caused by the water-soluble polymer in the mouth, as well as an improved feel when they are handled by the fingers.

Inventors:

ASARI DAISUKE (JP)
HORI MITSUHIKO (JP)
OGAWA KEIKO (JP)

Application Number:

PCT/JP2009/054335

Publication Date:

August 05, 2010

Filing Date:

March 06, 2009

Export Citation:

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Assignee:

NITTO DENKO CORP (JP)
ASARI DAISUKE (JP)
HORI MITSUHIKO (JP)
OGAWA KEIKO (JP)

International Classes:

A61K9/70; A61K47/10; A61K47/26; A61K47/32; A61K47/38

Foreign References:

JP2005342154A	2005-12-15
JP2004043450A	2004-02-12
JP2001504106A	2001-03-27
JP2007509172A	2007-04-12
JP2009051511A	2009-03-12

Other References: