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Title:
IODINATED TRIGLYCERIDE ANALOGS
Document Type and Number:
WIPO Patent Application WO2003080554
Kind Code:
A3
Abstract:
A compound represented by the following general formula (IA) or a salt thereof: wherein Ar>1< represents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Ar>2< represents an aryl group having at least one iodine atom as a substituent; L>1< AND L>2< independently represent a divalent bridging group of which main chain contains 6 or more carbon atoms; L>3< represents a single bond or a divalent bridging group of which main chain contains 1 to 6 carbon atoms and one oxygen atom; X represents a functional group containing at least one heteroatom, provided that, when L>3< is a single bond, X represents a functional group other than hydroxyl group. The compound can be used as a membrane component of liposomes, and the liposomes can be used as a contrast medium for X-ray radiography.

Inventors:
TAKAHASHI KAZUNOBU (JP)
KITAGUCHI HIROSHI (JP)
AIKAWA KAZUHIRO (JP)
Application Number:
JP0303814W
Publication Date:
April 15, 2004
Filing Date:
March 27, 2003
Export Citation:
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Assignee:
FUJI PHOTO FILM CO., LTD.
TAKAHASHI, KAZUNOBU
KITAGUCHI, HIROSHI
AIKAWA, KAZUHIRO
International Classes:
C07D295/14; A61K9/127; A61K49/04; A61K51/00; A61K51/12; C07C69/712; C07C69/734; C07C233/05; C07C275/14; C07C275/50; C07D295/15; C07D295/20; C07F9/09; C07F9/10; C07F9/117; (IPC1-7): C07D265/30; C07C233/11; C07C69/734; A61K51/12; A61K51/04; A61K49/04
Foreign References:
US6103216A2000-08-15
US4873075A1989-10-10
EP0037583A11981-10-14
Other References:
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M-L ALCARAZ ET AL.: "Synthesis and properties of photoactivatable phospholipid derivatives designed to probe the membrane-associate domains of proteins" JOURNAL OF ORGANIC CHEMISTRY, vol. 61, 1996, pages 192-201, XP002250373
B. CORSICO ET AL.: "Evidence for a central apolipoprotein A-I domain loosely bound to lipids in discoidal lipoproteins that us capable of penetrating the bilayer of phospholipid vesicles" JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 20, 2001, pages 16978-16985, XP002250374
Y. OGAWA ET AL.: "Regioselective photolabeling of glycoprotein A in membranes" CHEM. EUR. JOURNAL, vol. 8, no. 8, 2002, pages 1843-1849, XP002250375
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