Title:
ION ANALYZER
Document Type and Number:
WIPO Patent Application WO/2021/014487
Kind Code:
A1
Abstract:
This ion analyzer for generating product ions by emitting a prescribed type of radical onto sample-component-derived precursor ions and analyzing the product ions is provided with: a reaction chamber (2); a radical supply unit (5, 6) for generating radicals and supplying the same to the reaction chamber; a radical temperature acquisition unit (911, 912) for acquiring the temperature of radicals supplied to the reaction chamber; a standard material supply unit (11) for supplying, to the reaction chamber, a prescribed amount of prescribed precursor ions generated from a standard material having a known radical addition reaction activation energy; an ion measurement unit (92) for measuring the amount of prescribed product ions generated from the standard-material-derived precursor ions through reaction with the radicals; a radical reaction amount calculation unit (93) for using the amount of product ions to determine the amount of radicals that have reacted; and a radical density calculation unit (94) for determining the radical density on the basis of the radical temperature, the activation energy, and the amount of radicals that have reacted.
Inventors:
TAKAHASHI HIDENORI (JP)
ASAKAWA DAIKI (JP)
ASAKAWA DAIKI (JP)
Application Number:
PCT/JP2019/028418
Publication Date:
January 28, 2021
Filing Date:
July 19, 2019
Export Citation:
Assignee:
SHIMADZU CORP (JP)
AIST (JP)
AIST (JP)
International Classes:
G01N27/62; H01J49/10; H01J49/16; H01J49/42
Domestic Patent References:
| WO2015133259A1 | 2015-09-11 | |||
| WO2018186286A1 | 2018-10-11 |
Foreign References:
| US7476853B2 | 2009-01-13 | |||
| US20190195887A1 | 2019-06-27 |
Other References:
SHIMABUKURO, YUJI ET AL.: "Tandem Mass Spectrometry of Peptide Ions by Microwave Excited Hydrogen and Water Plasmas", ANALYTICAL CHEMISTRY, vol. 90, 2018, pages 7239 - 7245, XP055787273
TAKAHASHI, HIDENORI ET AL.: "Hydrogen Attachment/Abstraction Dissociation (HAD) of Gas-Phase Peptide Ions for Tandem Mass Spectrometry", ANALYTICAL CHEMISTRY, vol. 88, 2016, pages 3810 - 3816, XP055546231, DOI: 10.1021/acs.analchem.5b04888
TAKAHASHI, HIDENORI ET AL.: "Hydrogen Attachment/Abstraction Dissociation (HAD) of Gas-Phase Peptide Ions for Tandem Mass Spectrometry", ANALYTICAL CHEMISTRY, vol. 88, 2016, pages 3810 - 3816, XP055546231, DOI: 10.1021/acs.analchem.5b04888
Attorney, Agent or Firm:
KYOTO INTERNATIONAL PATENT LAW OFFICE (JP)
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