Title:
ION BINDING COMPOUNDS, RADIONUCLIDE COMPLEXES, METHODS OF MAKING RADIONUCLIDE COMPLEXES, METHODS OF EXTRACTING RADIONUCLEIDES, AND METHODS OF DELIVERING RADIONUCLIDES TO TARGET LOCATIONS
Document Type and Number:
WIPO Patent Application WO1999024396
Kind Code:
A8
Abstract:
The invention pertains to compounds for binding lanthanide ions and actinide ions. The invention further pertains to compounds for binding radionuclides, and to methods of making radionuclide complexes. Also, the invention pertains to methods of extracting radionuclides. Additionally, the invention pertains to methods of delivering radionuclides to target locations. In one aspect, the invention includes a compound comprising: a) a calix[n]arene group, wherein n is an integer greater than 3, the calix[n]arene group comprising an upper rim and a lower rim; b) at least one ionizable group attached to the lower rim; and c) an ion selected from the group consisting of lanthanide and actinide elements bound to the ionizable group. In another aspect, the invention includes a method of extracting a radionuclide, comprising: a) providing a sample comprising a radionuclide; b) providing a calix[n]arene compound in contact with the sample, wherein n is an integer greater than 3; and c) extracting radionuclide from the sample into the calix[n]arene compound. In yet another aspect, the invention includes a method of delivering a radionuclide to a target location, comprising: a) providing a calix[n]arene compound, wherein n is an integer greater than 3, the calix[n]arene compound comprising at least one ionizable group; b) providing a radionuclide bound to the calix[n]arene compound; and c) providing an antibody attached to the calix[n]arene compound, the antibody being specific for a material found at the target location.
Inventors:
CHEN XIAOYUAN
WAI CHIEN M
FISHER DARRELL R
WAI CHIEN M
FISHER DARRELL R
Application Number:
PCT/US1998/024074
Publication Date:
June 17, 1999
Filing Date:
November 12, 1998
Export Citation:
Assignee:
BATTELLE MEMORIAL INSTITUTE (US)
IDAHO RES FOUND (US)
IDAHO RES FOUND (US)
International Classes:
A61K47/48; A61K51/12; C07C259/06; C07C311/29; C22B3/26; C22B3/32; C22B59/00; C22B60/00; G21F9/12; (IPC1-7): C07C259/06; C07C59/74; C07C311/29; A61K51/04; C22B60/00
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