Title:
ION-DETECTING SENSORS COMPRISING PLASTICIZER-FREE COPOLYMERS
Document Type and Number:
WIPO Patent Application WO2004106893
Kind Code:
A3
Abstract:
Plasticizer-free ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers and a polymerizable ion exchanger, wherein the methacrylated monomers have pendent alkyl groups of different length and wherein the functionalized ion-exchanger is grafted into the copolymer through coval ent linkages. The ion exchanger comprises a C-derivative of a halogenated closo-dodecacarborane anion having a polymerizable moiety. Sensors of this invention include carrier-based ion-selective electrodes or optodes such as thin film ion-specific optodes, particle-based optodes, or bulk optodes.
Inventors:
BAKKER ERIC (US)
QIN YU (US)
QIN YU (US)
Application Number:
PCT/US2004/017226
Publication Date:
July 21, 2005
Filing Date:
May 28, 2004
Export Citation:
Assignee:
BECKMAN COULTER INC (US)
BAKKER ERIC (US)
QIN YU (US)
BAKKER ERIC (US)
QIN YU (US)
International Classes:
C07C69/52; C07F5/02; C08F220/14; C08F220/18; C08F265/04; G01N21/64; G01N27/26; G01N27/333; G01N33/20; G01N; (IPC1-7): G01N27/333; C07C69/52; C07F5/02; G01N21/64; G01N33/20
Foreign References:
| US6143570A | 2000-11-07 | |||
| US6277330B1 | 2001-08-21 | |||
| US5731470A | 1998-03-24 | |||
| US5747349A | 1998-05-05 |
Other References:
XIE Z. ET AL: "New Weakly Coordinating Anions. III. Useful Silver and Trityl Salt Reagents of Carborane Anions", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 116, no. 5, 1994, pages 1907 - 1913, XP008100908
XIE Z. ET AL: "Highly Chlorinated Brominated, and Iodinated Icosahedral Carborane Anions: 1-H-CB11X11-, 1-CH3-CB11X11-(X=C1, Br, I); 1Br-CB11Br11", INORGANIOC CHEMISTRY, vol. 37, no. 25, 1998, pages 6444 - 6451, XP008102781
PEPER S. ET AL: "Perbrominated closo-Dodecacarborane Anion, 1-HCB11Br11-, as an Ion Exchanger in Cation-Selective Chemical Sensors", ANALYTICAL CHEMISTRY, vol. 74, no. 6, 15 March 2002 (2002-03-15), pages 1327 - 1332, XP001153336
ROSATZIN T. ET AL: "Immobilization of components in polymer membrane-based calcium-selective bulk optodes", ANALYTICAL CHEMISTRY, vol. 64, no. 18, 15 September 1992 (1992-09-15), pages 2029 - 2035, XP002300961
GEHRIG P. ET AL: "Very lipophilic calcium(2+)-selective ionophore for chemical sensors of high leifetime", CHIMIA, vol. 43, no. 12, December 1989 (1989-12-01), pages 377 - 379, XP001537063
PRETSCH E. ET AL: "Ionophores of the Type of 3-Oxapentane Diamides", HELVETICA CHIMICA ACTA, vol. 63, no. 16, pages 191 - 196, XP008102769
See also references of EP 1634051A4
XIE Z. ET AL: "Highly Chlorinated Brominated, and Iodinated Icosahedral Carborane Anions: 1-H-CB11X11-, 1-CH3-CB11X11-(X=C1, Br, I); 1Br-CB11Br11", INORGANIOC CHEMISTRY, vol. 37, no. 25, 1998, pages 6444 - 6451, XP008102781
PEPER S. ET AL: "Perbrominated closo-Dodecacarborane Anion, 1-HCB11Br11-, as an Ion Exchanger in Cation-Selective Chemical Sensors", ANALYTICAL CHEMISTRY, vol. 74, no. 6, 15 March 2002 (2002-03-15), pages 1327 - 1332, XP001153336
ROSATZIN T. ET AL: "Immobilization of components in polymer membrane-based calcium-selective bulk optodes", ANALYTICAL CHEMISTRY, vol. 64, no. 18, 15 September 1992 (1992-09-15), pages 2029 - 2035, XP002300961
GEHRIG P. ET AL: "Very lipophilic calcium(2+)-selective ionophore for chemical sensors of high leifetime", CHIMIA, vol. 43, no. 12, December 1989 (1989-12-01), pages 377 - 379, XP001537063
PRETSCH E. ET AL: "Ionophores of the Type of 3-Oxapentane Diamides", HELVETICA CHIMICA ACTA, vol. 63, no. 16, pages 191 - 196, XP008102769
See also references of EP 1634051A4
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