Title:
ION GUIDE DEVICE, ION REACTOR, AND MASS ANALYZER
Document Type and Number:
WIPO Patent Application WO/2007/060755
Kind Code:
A1
Abstract:
This invention relates to a sequence structure analysis of a biopolymer using a
mass analysis method. A time of not less than 10 msec is necessary for a charged particle
reaction, and this poses a problem that coupling with a high speed analysis part
such as a quadrupole mass filter causes a lowering in throughput or mass separation capability.
Accordingly, a charge particle reaction, which can be coupled with the high speed
analysis part, should be carried out while regulating an ion residence time to
ensure the reaction time. A charged particle reaction cell comprising a plurality
of ring electrodes (1) placed side by side is provided. A modulated high frequency
voltage obtained by modulating the amplitude of a high frequency voltage is applied.
In this case, ions are captured on the bottom of ups and downs of the formed pseudo
potential, and the movement thereof causes ion migration. In the charged particle
reaction cell, the time necessary for the charged particle reaction can be ensured.
Further, the problem of lowered throughput and mass separation capability can
be solved, and, thus, the speed of the structure analysis of a measurement sample
can be accelerated.
Inventors:
SATAKE HIROYUKI (JP)
BABA TAKASHI (JP)
WAKI IZUMI (JP)
BABA TAKASHI (JP)
WAKI IZUMI (JP)
Application Number:
PCT/JP2006/304498
Publication Date:
May 31, 2007
Filing Date:
March 08, 2006
Export Citation:
Assignee:
HITACHI LTD (JP)
SATAKE HIROYUKI (JP)
BABA TAKASHI (JP)
WAKI IZUMI (JP)
SATAKE HIROYUKI (JP)
BABA TAKASHI (JP)
WAKI IZUMI (JP)
International Classes:
G01N27/62; H01J40/06; G21K1/00; H01J49/26
Foreign References:
| US20040031916A1 | 2004-02-19 | |||
| JP2004520685A | 2004-07-08 | |||
| JP2003045372A | 2003-02-14 | |||
| JP2005341365A | 2005-12-08 | |||
| US6800851B1 | 2004-10-05 | |||
| US20040155180A1 | 2004-08-12 | |||
| US6884995B2 | 2005-04-26 |
Other References:
JOHN E. P. SYKA ET AL., PNAS, vol. 101, no. 26, pages 9528 - 9533
TAKASHI BABA ET AL., ANALYTICAL CHEMISTRY, vol. 76, 2004, pages 4263 - 4266
H. G. DEHMELT ET AL., ADV. AT. MOLPHYS, vol. 353, 1967, pages 53 - 72
See also references of EP 1956635A4
TAKASHI BABA ET AL., ANALYTICAL CHEMISTRY, vol. 76, 2004, pages 4263 - 4266
H. G. DEHMELT ET AL., ADV. AT. MOLPHYS, vol. 353, 1967, pages 53 - 72
See also references of EP 1956635A4
Attorney, Agent or Firm:
ASAMURA, Kiyoshi et al. (New Ohtemachi Bldg. 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo 04, JP)
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