Title:
IONIZABLE DILSULFIDE LIPIDS AND LIPID NANOPARTICLES DERIVED THEREFROM
Document Type and Number:
WIPO Patent Application WO/2023/115221
Kind Code:
A9
Abstract:
Ionizable lipids with a disulfide moiety and lipid nanoparticles comprising said lipids are disclosed. In select preferred embodiments, the ionizable lipids have a structure of formulae 11-15. The lipid nanoparticles formed from the ionizable lipids can be used as delivery vehicles for medicinal small molecules, antibodies, nucleotides, and polypeptides. Such nanoparticles can be used as vaccines or the treatment of cancer.
Inventors:
GOPALAKRISHNA PANICKER RAJESH KRISHNAN (CA)
KARPOV YURY (CA)
OLSEN KIRSTIN (CA)
KARPOV YURY (CA)
OLSEN KIRSTIN (CA)
Application Number:
PCT/CA2022/051889
Publication Date:
January 25, 2024
Filing Date:
December 22, 2022
Export Citation:
Assignee:
PROVIDENCE THERAPEUTICS HOLDINGS INC (CA)
International Classes:
C07C323/52; A61K9/51; A61K39/00; A61K47/20; A61P35/00; A61P37/04
Attorney, Agent or Firm:
ROBIC AGENCE PI S.E.C./ROBIC IP AGENCY LP (CA)
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