Title:
IP-10 ANTIBODIES AND THEIR USES
Document Type and Number:
WIPO Patent Application WO2005058815
Kind Code:
A3
Abstract:
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP- 10 with high affinity, inhibit the binding of IP- 10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
Inventors:
DESHPANDE SHRIKANT (US)
HUANG HAICHUN (US)
SRINIVASAN MOHAN (US)
CARDARELLI JOSEPHINE M (US)
WANG CHANGYU (US)
PASSMORE DAVID (US)
RANGAN VANGIPURAM S (US)
LANE THOMAS E (US)
KEIRSTEAD HANS S (US)
LIU MICHAEL T (US)
HUANG HAICHUN (US)
SRINIVASAN MOHAN (US)
CARDARELLI JOSEPHINE M (US)
WANG CHANGYU (US)
PASSMORE DAVID (US)
RANGAN VANGIPURAM S (US)
LANE THOMAS E (US)
KEIRSTEAD HANS S (US)
LIU MICHAEL T (US)
Application Number:
PCT/US2004/041506
Publication Date:
February 23, 2006
Filing Date:
December 10, 2004
Export Citation:
Assignee:
MEDAREX INC (US)
DESHPANDE SHRIKANT (US)
HUANG HAICHUN (US)
SRINIVASAN MOHAN (US)
CARDARELLI JOSEPHINE M (US)
WANG CHANGYU (US)
PASSMORE DAVID (US)
RANGAN VANGIPURAM S (US)
LANE THOMAS E (US)
KEIRSTEAD HANS S (US)
LIU MICHAEL T (US)
DESHPANDE SHRIKANT (US)
HUANG HAICHUN (US)
SRINIVASAN MOHAN (US)
CARDARELLI JOSEPHINE M (US)
WANG CHANGYU (US)
PASSMORE DAVID (US)
RANGAN VANGIPURAM S (US)
LANE THOMAS E (US)
KEIRSTEAD HANS S (US)
LIU MICHAEL T (US)
International Classes:
A61K39/395; C07K14/52; C07K16/24; C07K16/28; C07D; (IPC1-7): A61K39/395; C12N5/10; C12N15/00; C12N15/63; C07H21/04
Foreign References:
| US20030166589A1 | 2003-09-04 |
Other References:
REFF M.E. ET AL: "A review of modifications to recombinant antibodies: attempt to increase efficacy in oncology applications", CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY, vol. 40, January 2001 (2001-01-01), pages 25 - 35, XP002329383
KOLB S.A. ET AL: "Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1-infected individuals as interferon-gamma inducible protein 10", JOURNAL OF NEUROIMMUNOLOGY, vol. 93, September 1999 (1999-09-01), pages 172 - 181, XP002198988
KOLB S.A. ET AL: "Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1-infected individuals as interferon-gamma inducible protein 10", JOURNAL OF NEUROIMMUNOLOGY, vol. 93, September 1999 (1999-09-01), pages 172 - 181, XP002198988
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