Title:
IPG ANTAGONISTS FOR THE TREATMENT OF CONDITIONS INVOLVING MAST CELLS, BASOPHILS AND EOSINOPHILS
Document Type and Number:
WIPO Patent Application WO1999049855
Kind Code:
A3
Abstract:
This application discloses that inositolphosphoglycans (IPGs) can be obtained from basophils, eosinophils and mast cells and that allergen stimulation of these cells results in IPG release. It also shows that IPGs are second messengers for allergic stimulation as the addition of some types of purified IPGs to non-allergen stimulated cells resulted in histamine release or degranulation. Thus, IPG antagonists can be used for the treatment of conditions (especially allergy and asthma) mediated by the release of IPGs from mast cells, basophils or eosinophils. Preferred IPG antagonists include anti-IPG antibodies, inhibitors of the enzyme GPI-PLD and competitive antagonists.
Inventors:
RADEMACHER THOMAS WILLIAM (GB)
WHITBY HELEN (GB)
WHITBY HELEN (GB)
Application Number:
PCT/GB1999/000981
Publication Date:
November 18, 1999
Filing Date:
March 29, 1999
Export Citation:
Assignee:
UNIV LONDON (GB)
RADEMACHER THOMAS WILLIAM (GB)
WHITBY HELEN (GB)
RADEMACHER THOMAS WILLIAM (GB)
WHITBY HELEN (GB)
International Classes:
A61K31/00; A61K31/70; A61K45/00; A61K31/7004; A61K38/00; A61K39/395; A61P11/00; A61P11/06; A61P17/00; A61P37/08; A61P43/00; C07K16/18; (IPC1-7): A61K31/70; A61K39/395
Domestic Patent References:
| WO1998010791A1 | 1998-03-19 | |||
| WO1998011435A1 | 1998-03-19 | |||
| WO1998011117A1 | 1998-03-19 | |||
| WO1998011116A1 | 1998-03-19 | |||
| WO1996029425A1 | 1996-09-26 |
Other References:
RADEMACHER T W ET AL: "Inositolphosphoglycan second messengers.", BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, (1994 FEB) 27 (2) 327-41., XP002050248
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