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Title:
IRAK4 DEGRADATION AGENT, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/025159
Kind Code:
A1
Abstract:
An IRAK4 degradation agent as represented by structural formula PTM-L-ULM (I), and a preparation method therefor and the use thereof. The provided compound can effectively inhibit and/or degrade IRAK4 kinase protein in a cell and inhibit an immune cell from producing IL-6.

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Inventors:
YE ZHENGQING (CN)
FENG YAN (CN)
LI SHIQIANG (CN)
Application Number:
PCT/CN2022/114323
Publication Date:
March 02, 2023
Filing Date:
August 23, 2022
Export Citation:
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Assignee:
SHANGHAI LEADINGTAC PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D471/10; A61K31/513; A61P25/08; A61P35/00; A61P35/02; C07D401/14; C07D403/12
Domestic Patent References:
WO2022028547A12022-02-10
WO2022147465A12022-07-07
WO2019099926A12019-05-23
WO2020113233A12020-06-04
WO2020264499A12020-12-30
WO2019160915A12019-08-22
WO2022088551A12022-05-05
WO2019160915A12019-08-22
WO2020113233A12020-06-04
Foreign References:
CN110612294A2019-12-24
CN202110966608A2021-08-23
CN202210558158A2022-05-19
CN202210989448A2022-08-17
US20190151295A12019-05-23
US20190192688A12019-06-27
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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