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Title:
IRAK4 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/001461
Kind Code:
A1
Abstract:
The invention relates to an IRAK4 inhibitor and uses thereof in preparing a drug treating IRAK4-associated diseases. More specifically, the invention relates to said compound represented by formula (I) and a pharmaceutically acceptable salt thereof. (I)

Inventors:
ZHANG YANG (CN)
WANG YIKAI (CN)
CHEN LINLIN (CN)
ZHOU LILI (CN)
FANG YONGBO (CN)
FENG TAO (CN)
CHEN SHUHUI (CN)
Application Number:
PCT/CN2018/093090
Publication Date:
January 03, 2019
Filing Date:
June 27, 2018
Export Citation:
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Assignee:
MEDSHINE DISCOVERY INC (CN)
International Classes:
C07D495/14; A61K31/4365; A61K31/5377; A61P17/06; A61P19/02; A61P19/06; A61P35/00; C07D495/04
Domestic Patent References:
WO2014011902A12014-01-16
Foreign References:
CN104582705A2015-04-29
CN105142639A2015-12-09
US20140018361A12014-01-16
Other References:
SCOTT, J.S. ET AL.: "Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin 1 Receptor Associated Kinase 4 ( IRAK 4) for the Treatment of Mutant MYD88L265P Diffuse Large B Cell Lymphoma", J. MED. CHEM., vol. 60, 27 November 2017 (2017-11-27), pages 10071 - 10091, XP055562599
KELLY, P.N ET AL.: "Selective Interleukin 1 Receptor Associated Kinase 4 Inhibitors for the Treatment of Autoimmune Disorders and Lymphoid Malignancy", J. EXP. MED., vol. 212, no. 13, 31 December 2015 (2015-12-31), pages 2189 - 2201, XP055562600
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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