IRON OXIDE NANOCAPSULES, METHOD OF MANUFACTURING THE SAME, AND MRI CONTRAST AGENT USING THE SAME

Title:

IRON OXIDE NANOCAPSULES, METHOD OF MANUFACTURING THE SAME, AND MRI CONTRAST AGENT USING THE SAME

Document Type and Number:

WIPO Patent Application WO/2012/030134

Kind Code:

A3

Abstract:

Provided are iron oxide nanocapsules for an MRI contrast agent having high contrast, in which a plurality of iron oxide nanopart icles having a hydrophobic ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below. Also a method of manufacturing the iron oxide nanocapsules is provided. [Relation 1] 5 ≤ 100* Dm(I0)/ Cv(I0) [Relation 2] 2.5 ≤ 100* Dm(Cap)/ Cv(Cap) [Relation 3] 0.5 wt% < F(I0) < 50 wt% [Relation 4] 1 nm < Dm(I0) < 25 nm [Relation 5] 50 nm < Dm(Cap) ≤ 200 nm.

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Inventors:

JEON BONG-SIK (KR)
KIM EUNG GYU (KR)
KWON EUN BYUL (KR)
PARK JU YOUNG (KR)
MYEONG WAN JAE (KR)

Application Number:

PCT/KR2011/006396

Publication Date:

June 28, 2012

Filing Date:

August 30, 2011

Export Citation:

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Assignee:

HANWHA CHEMICAL CORP (KR)
JEON BONG-SIK (KR)
KIM EUNG GYU (KR)
KWON EUN BYUL (KR)
PARK JU YOUNG (KR)
MYEONG WAN JAE (KR)

International Classes:

B82B3/00; A61K49/06

Foreign References:

KR20060084702A	2006-07-25
KR20090085834A	2009-08-10
KR20040092969A	2004-11-04
KR20010031289A	2001-04-16

Other References: