Title:
ISARIDIN CYCLIC LIPOPEPTIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/130740
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of biological medicines, and particularly relates to an isaridin cyclic lipopeptide derivative, and a preparation method therefor and the use thereof. Tests prove that the derivative shows good anti-inflammatory and antithrombotic activity, which is even higher than that of the positive control drug. Moreover, the marine microorganism-derived natural compound has the characteristics of not being prone to resistance, having high safety, etc., and tests also prove that the cytotoxicity of the compound is low. Furthermore, the isaridin cyclic depsipeptide derivative is extracted from ascidian symbiotic and epiphyte fungi, can be subjected to scale fermentation by using microorganisms, has the characteristics of a simple production process, a short period, low product cost, etc., and has a wide application prospect.
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Inventors:
CHEN SENHUA (CN)
LIU LAN (CN)
JIANG MINGHUA (CN)
LIU LAN (CN)
JIANG MINGHUA (CN)
Application Number:
PCT/CN2022/114544
Publication Date:
July 13, 2023
Filing Date:
August 24, 2022
Export Citation:
Assignee:
UNIV SUN YAT SEN (CN)
International Classes:
C07K7/64; A61K38/08; A61K38/12; A61P7/02; A61P29/00; C07K7/02; C07K7/06; C12P21/02; C12P21/04
Foreign References:
| CN114085272A | 2022-02-25 | |||
| CN112646729A | 2021-04-13 | |||
| CN107344957A | 2017-11-14 | |||
| CN112795609A | 2021-05-14 |
Other References:
CHUNG YU-MING, EL-SHAZLY MOHAMED, CHUANG DA-WEI, HWANG TSONG-LONG, ASAI TEIGO, OSHIMA YOSHITERU, ASHOUR MOHAMED L., WU YANG-CHANG,: "Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, Induces the Production of Anti-inflammatory Cyclodepsipeptides from Beauveria felina", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 76, no. 7, 26 July 2013 (2013-07-26), US , pages 1260 - 1266, XP093076954, ISSN: 0163-3864, DOI: 10.1021/np400143j
PAN NI, LI ZI-CHENG, LI ZHI-HONG, CHEN SEN-HUA, JIANG MING-HUA, YANG HAN-YAN, LIU YAO-SHENG, HU RUI, ZENG YU-WEI, DAI LE-HUI, LIU : "Antiplatelet and Antithrombotic Effects of Isaridin E Isolated from the Marine-Derived Fungus via Downregulating the PI3K/Akt Signaling Pathway", MARINE DRUGS, vol. 20, no. 1, 24 December 2021 (2021-12-24), pages 23, XP093076958, DOI: 10.3390/md20010023
CHE, YONGSHENG ET AL.: "Pseudodestruxins A and B: New Cyclic Depsipeptides from the Coprophilous Fungus Nigrosabulum globosum;", JOURNAL OF NATURAL PRODUCTS;, vol. 64, no. 5, 30 May 2001 (2001-05-30), XP055169976, DOI: 10.1021/np000547r
PAN NI, LI ZI-CHENG, LI ZHI-HONG, CHEN SEN-HUA, JIANG MING-HUA, YANG HAN-YAN, LIU YAO-SHENG, HU RUI, ZENG YU-WEI, DAI LE-HUI, LIU : "Antiplatelet and Antithrombotic Effects of Isaridin E Isolated from the Marine-Derived Fungus via Downregulating the PI3K/Akt Signaling Pathway", MARINE DRUGS, vol. 20, no. 1, 24 December 2021 (2021-12-24), pages 23, XP093076958, DOI: 10.3390/md20010023
CHE, YONGSHENG ET AL.: "Pseudodestruxins A and B: New Cyclic Depsipeptides from the Coprophilous Fungus Nigrosabulum globosum;", JOURNAL OF NATURAL PRODUCTS;, vol. 64, no. 5, 30 May 2001 (2001-05-30), XP055169976, DOI: 10.1021/np000547r
Attorney, Agent or Firm:
WAYNE INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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