ISOINDAZOLE COMPOUND - GREEN CROSS CORP

Title:

ISOINDAZOLE COMPOUND

Document Type and Number:

WIPO Patent Application WO/1993/019060

Kind Code:

A1

Abstract:

An isoindazole compound represented by general formula (1) or a salt thereof, a process for producing the same, and a pharmaceutical use thereof, in particular, as an angiotensin II antagonist and a prophylactic and/or therapeutic agent for circulatory organ diseases such as hypertension and cardiac insufficiency, wherein Q represents a heterocyclic group represented by general formula (2) or (3), and other symbols are each as defined in the specification. The above compound and salt have an excellent angiotensin II antagonism and reduced toxicity, thus being useful as an angiotensin II antagonist for treating or preventing various diseases mediated by angiotensin II, such as circulatory organ diseases, for example, hypertensions including essential and renal ones, cardiac insufficiency, and so forth.

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Inventors:

INOUE YOSHIHISA (JP)
EBISU HAJIME (JP)
NAKAMURA NORIFUMI (JP)
MORIZAWA YOSHITOMI (JP)
OKAZOE TAKASHI (JP)

Application Number:

PCT/JP1993/000354

Publication Date:

September 30, 1993

Filing Date:

March 25, 1993

Export Citation:

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Assignee:

GREEN CROSS CORP (JP)
ASAHI GLASS CO LTD (JP)

International Classes:

C07D403/06; C07D471/04; C07D473/00; (IPC1-7): A61K31/415; A61K31/435; A61K31/52; C07D403/06; C07D403/14; C07D471/04; C07D473/00; C07D473/40

Foreign References:

JPH03501020A	1991-03-07
JPH0395181A	1991-04-19
JPH03271288A	1991-12-03
JPH03236377A	1991-10-22

Other References: