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Title:
ISOLATED ADULT CELLS, ARTIFICIAL ORGANS,REHABILITATED ORGANS, RESEARCH ROOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME
Document Type and Number:
WIPO Patent Application WO/2011/002926
Kind Code:
A3
Abstract:
One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ.

Inventors:
YARMUSH MARTIN (US)
UYGUN BASAK E (US)
UYGUN KORKUT (US)
IZAMIS MARIA LOUISA (US)
SOTO-GUTIERREZ ALEJANDRO (US)
TOLBOOM HERMAN (CH)
YAGI HIROSHI (US)
SHULMAN CARLEY (US)
MILWID JACK (US)
Application Number:
PCT/US2010/040663
Publication Date:
May 19, 2011
Filing Date:
June 30, 2010
Export Citation:
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Assignee:
GEN HOSPITAL CORP (US)
MASSACHUSETTS INST TECHNOLOGY (US)
YARMUSH MARTIN (US)
UYGUN BASAK E (US)
UYGUN KORKUT (US)
IZAMIS MARIA LOUISA (US)
SOTO-GUTIERREZ ALEJANDRO (US)
TOLBOOM HERMAN (CH)
YAGI HIROSHI (US)
SHULMAN CARLEY (US)
MILWID JACK (US)
International Classes:
C12N5/07; A01N1/02; A61F2/02
Foreign References:
US7504201B22009-03-17
US20090123437A12009-05-14
US20080288399A12008-11-20
EP1246903A12002-10-09
Attorney, Agent or Firm:
LAURO, Peter C. et al. (P.O.Box 55874Boston, MA, US)
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