Title:
ISOLATED HUMAN TUMOR SUPRESSOR PROTEINS, NUCLEIC ACID MOLECULES ENCODING THESE HUMAN TUMOR SUPRESSOR PROTEINS, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2002068468
Kind Code:
A3
Abstract:
The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the tumor supressor protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the tumor supressor protein polypeptides, and methods of identifying modulators of the tumor supressor protein polypeptides.
Inventors:
GONG FANGCHENG
YAN CHUNHUA
YAN CHUNHUA
Application Number:
PCT/US2002/003235
Publication Date:
April 17, 2003
Filing Date:
February 05, 2002
Export Citation:
Assignee:
PE CORP NY (US)
International Classes:
C07K14/47; C12N1/21; C12N15/12; (IPC1-7): C07K14/47; A01K67/027; C07K16/18; C12N1/21; C12N5/10; C12N15/00; C12N15/12; C12Q1/68; G01N33/68
Domestic Patent References:
| WO1997021809A1 | 1997-06-19 | |||
| WO1998044102A2 | 1998-10-08 | |||
| WO1999016790A1 | 1999-04-08 | |||
| WO2000046370A1 | 2000-08-10 | |||
| WO2001059114A2 | 2001-08-16 | |||
| WO2001047959A2 | 2001-07-05 |
Other References:
GARKAVSTEV I ET AL: "SUPPRESSION OF THE NOVEL GROWTH INHIBITOR P33ING1 PROMOTES NEOPLASTIC TRANSFORMATION", NATURE GENETICS, NATURE AMERICA, NEW YORK, US, vol. 23, no. 3, November 1999 (1999-11-01), pages 373, XP000982367, ISSN: 1061-4036
GARKAVTSEV I ET AL: "SUPPRESSION OF THE NOVEL GROWTH INHIBITOR P33ING1 PROMOTES NEOPLASTIC TRANSFORMATION", NATURE GENETICS, NEW YORK, NY, US, vol. 14, December 1996 (1996-12-01), pages 415 - 420, XP002948506, ISSN: 1061-4036
GUNDUZ MEHMET ET AL: "Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.", CANCER RESEARCH, vol. 60, no. 12, 15 June 2000 (2000-06-15), pages 3143 - 3146, XP002229000, ISSN: 0008-5472
DATABASE EMBL [online] EMBL; XP002229002, retrieved from EBI accession no. AF181850 Database accession no. AF181850
DATABASE EMBL [online] EMBL; 6 August 2000 (2000-08-06), OUCHIDA M ET AL, XP002229003, retrieved from EBI accession no. AB037387 Database accession no. AB037387
DATABASE EMBL [online] EMBL; 16 February 2000 (2000-02-16), XP002229004, retrieved from EBI accession no. AL139385 Database accession no. AL139385
DATABASE EMBL [online] EMBL; 12 September 2000 (2000-09-12), XP002229005, retrieved from EBI accession no. AF078835 Database accession no. AF078835
DATABASE EMBL [online] EMBL; XP002229006, retrieved from EBI accession no. Q9NS83 Database accession no. Q9NS83
DATABASE EMBL [online] EMBL; 1 May 2000 (2000-05-01), XP002229007, retrieved from EBI accession no. Q9UK53 Database accession no. Q9UK53
DATABASE EMBL [online] EMBL; 1 May 2000 (2000-05-01), XP002229008, retrieved from EBI accession no. Q9UK52 Database accession no. Q9UK52
NAGASHIMA MAKOTO ET AL: "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 98, no. 17, 14 August 2001 (2001-08-14), August 14, 2001, pages 9671 - 9676, XP002229001, ISSN: 0027-8424
GARKAVTSEV I ET AL: "SUPPRESSION OF THE NOVEL GROWTH INHIBITOR P33ING1 PROMOTES NEOPLASTIC TRANSFORMATION", NATURE GENETICS, NEW YORK, NY, US, vol. 14, December 1996 (1996-12-01), pages 415 - 420, XP002948506, ISSN: 1061-4036
GUNDUZ MEHMET ET AL: "Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.", CANCER RESEARCH, vol. 60, no. 12, 15 June 2000 (2000-06-15), pages 3143 - 3146, XP002229000, ISSN: 0008-5472
DATABASE EMBL [online] EMBL; XP002229002, retrieved from EBI accession no. AF181850 Database accession no. AF181850
DATABASE EMBL [online] EMBL; 6 August 2000 (2000-08-06), OUCHIDA M ET AL, XP002229003, retrieved from EBI accession no. AB037387 Database accession no. AB037387
DATABASE EMBL [online] EMBL; 16 February 2000 (2000-02-16), XP002229004, retrieved from EBI accession no. AL139385 Database accession no. AL139385
DATABASE EMBL [online] EMBL; 12 September 2000 (2000-09-12), XP002229005, retrieved from EBI accession no. AF078835 Database accession no. AF078835
DATABASE EMBL [online] EMBL; XP002229006, retrieved from EBI accession no. Q9NS83 Database accession no. Q9NS83
DATABASE EMBL [online] EMBL; 1 May 2000 (2000-05-01), XP002229007, retrieved from EBI accession no. Q9UK53 Database accession no. Q9UK53
DATABASE EMBL [online] EMBL; 1 May 2000 (2000-05-01), XP002229008, retrieved from EBI accession no. Q9UK52 Database accession no. Q9UK52
NAGASHIMA MAKOTO ET AL: "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 98, no. 17, 14 August 2001 (2001-08-14), August 14, 2001, pages 9671 - 9676, XP002229001, ISSN: 0027-8424
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