Title:
ISOLATION, IDENTIFICATION, AND USED OF ANTIFUNGAL COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2013/096697
Kind Code:
A3
Abstract:
In one aspect, the invention relates to isolated compounds useful as antifungal agents, for example, compounds having a structure represented by a formula: wherein R1 is hydrogen or hydroxyl; wherein R2 is hydrogen, a-xylose or β -xylose; and wherein R3 and R4 are each hydrogen or together oxygen, or a pharmaceutically acceptable salt therof; methods of isolating and puifying same; pharmaceutical compositions comprising same; agricultural compositions comprising same; and methods of treating and/or preventing fungal infections using same. In one aspect, R2 is not hydrogen or β-xylose when R1 is hydroxyl and R3 and R4 are together oxygen This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Inventors:
SCHMIDT ERIC W (US)
FALKINHAM JOSEPH O (US)
JEFFS PETER W (US)
FALKINHAM JOSEPH O (US)
JEFFS PETER W (US)
Application Number:
PCT/US2012/071089
Publication Date:
June 18, 2015
Filing Date:
December 20, 2012
Export Citation:
Assignee:
UNIV UTAH RES FOUND (US)
International Classes:
A61K38/12; A61P31/10
Domestic Patent References:
| WO2011101631A1 | 2011-08-25 |
Foreign References:
| US20110136729A1 | 2011-06-09 | |||
| US5576298A | 1996-11-19 | |||
| US20100092526A1 | 2010-04-15 |
Other References:
TAWFIK ET AL.: "Burkholdines 1097 and 1229, Potent Antifungal Peptides from Burkholderia ambifaria 2.2N", ORGANIC LETTERS, vol. 12, no. 4, 2010, pages 664 - 666, Retrieved from the Internet [retrieved on 20100216]
LIN ET AL.: "Burkholdines from Burkholderia ambifaria: Antifungal Agents and Possible Virulence Factors", J. NAT. PROD., vol. 75, no. 9, 18 September 2012 (2012-09-18), pages 1518 - 1523, Retrieved from the Internet [retrieved on 20130216]
LIN ET AL.: "Burkholdines from Burkholderia ambifaria: Antifungal Agents and Possible Virulence Factors", J. NAT. PROD., vol. 75, no. 9, 18 September 2012 (2012-09-18), pages 1518 - 1523, Retrieved from the Internet
Attorney, Agent or Firm:
SHORTELL, D., Brian et al. (LLP999 Peachtree Street, Suite 100, Atlanta GA, US)
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