Title:
ISOLATION AND USE OF AMINE SALTS OF MYCOPHENOLIC ACID
Document Type and Number:
WIPO Patent Application WO2008003637
Kind Code:
B1
Abstract:
The present invention provides a method for the isolation of mycophenolic acid from a fermentation broth comprising the steps of: (a) Adding a water-immiscible solvent to said fermentation broth; (b) Separating the water-immiscible phase from the aqueous phase, and; (c) Adding an amine to the water-immiscible phase obtained in step (b). Furthermore, the present invention provides the use of mycophenolate amines in the preparation of mycophenolate esters, in particular mycophenolate mofetil, and mycophenolate salts, in particular mycophenolate sodium salt.
Inventors:
PATER DE ROBERTUS MATTHEUS (NL)
SANDT VAN DE EMILIUS JOHANNES (NL)
WEBER PIETER GIJSBERT (NL)
SANDT VAN DE EMILIUS JOHANNES (NL)
WEBER PIETER GIJSBERT (NL)
Application Number:
PCT/EP2007/056486
Publication Date:
July 03, 2008
Filing Date:
June 28, 2007
Export Citation:
Assignee:
DSM IP ASSETS BV (NL)
PATER DE ROBERTUS MATTHEUS (NL)
SANDT VAN DE EMILIUS JOHANNES (NL)
WEBER PIETER GIJSBERT (NL)
PATER DE ROBERTUS MATTHEUS (NL)
SANDT VAN DE EMILIUS JOHANNES (NL)
WEBER PIETER GIJSBERT (NL)
International Classes:
C07D307/88; A61K31/535
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