Title:
ISONITRILE BIOSYNTHETIC GENES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2007035693
Kind Code:
A9
Abstract:
Novel isonitrile biosynthetic enzymes isnA and isnB which together possess a catalytic activity of converting an amine-containing compound to an isonitrile-containing compound are described. The genes that encode such enzymes, recombinant vectors containing one or both of such genes, a host cell transformed with said vector, methods for the production and isolation of the enzymes of the invention are also described. Methods for the identification of bioactive, isonitrile-containing natural products derived from the biosynthetic activity of the enzymes of the invention, and methods for synthetically producing isonitrile-containing compounds from the isolated enzymes of the invention are also described.
Inventors:
CLARDY JON (US)
BRADY SEAN F (US)
BRADY SEAN F (US)
Application Number:
PCT/US2006/036401
Publication Date:
July 05, 2007
Filing Date:
September 19, 2006
Export Citation:
Assignee:
HARVARD COLLEGE (US)
CLARDY JON (US)
BRADY SEAN F (US)
CLARDY JON (US)
BRADY SEAN F (US)
International Classes:
C12N15/43; C12N9/10; C12N9/88; C12N15/60; C12P17/10
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