ISOPRENYL DERIVATIVES AND THEIR USE IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS AND CARDIOVASCULAR CALCIFICATION

Title:

ISOPRENYL DERIVATIVES AND THEIR USE IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS AND CARDIOVASCULAR CALCIFICATION

Document Type and Number:

WIPO Patent Application WO2003013420

Kind Code:

A3

Abstract:

A non-toxic biologically active compound is provided having the following general formula (I), wherein n is an integer from 1 to 14, preferably from 2 to 4, and R is an organic moiety, preferably a group different from but structurally substantially similar to 2-methyl naphthoquinone, or a group P-C(R1)-P, where each P stands for a -PO(OH)2 group and R1 is a (poly)isoprenyl group, hydroxy, halogen (preferably chloro or bromo), or hydrogen, or a pharmaceutically acceptable derivative thereof. These compounds are useful for the treatment or prevention of certain disorders in a mammal, especially a human being, for example postmenopausal loss of bone in women, juvenile or senile osteoporosis in men and women, cardiovascular calcification and other ectopic calcifications.

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Inventors:

VERMEER CEER (NL)

Application Number:

PCT/EP2002/008917

Publication Date:

November 06, 2003

Filing Date:

August 05, 2002

Export Citation:

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Assignee:

VITAK BV (NL)
VERMEER CEER (NL)

International Classes:

A61K6/00; A61P9/10; A61P19/10; C07C50/06; C07C50/14; C07C69/007; C07C69/616; C07C69/675; C07C69/78; (IPC1-7): C07C50/14; A61K31/122; A61P9/10; A61P19/10

Domestic Patent References:

WO1999000135A1

1999-01-07

Foreign References:

EP1153548A1	2001-11-14
EP0636598A1	1995-02-01
EP0243849A2	1987-11-04

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