Title:
ISOQUINOLIN AND NAPHTHYDRIN COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2018/157277
Kind Code:
A1
Abstract:
The present invention provides a compound of Formula (I), where in X is selected from the group consisting of CH and N; Q is selected from the group consisting of CH3 and H; R is selected from the group consisting of (II) and (III), or a pharmaceutically acceptable salt thereof, compositions, methods to treat liver disease and NASH.
Inventors:
LEI HUI (US)
LIU GANG (US)
TIAN YUAN (US)
ZHANG HAIZHEN (US)
LIU GANG (US)
TIAN YUAN (US)
ZHANG HAIZHEN (US)
Application Number:
PCT/CN2017/075121
Publication Date:
September 07, 2018
Filing Date:
February 28, 2017
Export Citation:
Assignee:
LILLY CO ELI (US)
LILLY CHINA RES AND DEVELOPMENT CO LTD (CN)
LILLY CHINA RES AND DEVELOPMENT CO LTD (CN)
International Classes:
C07D453/06; A61K31/4196; A61P31/12; A61P37/02; C07D471/02
Foreign References:
| CN104080771A | 2014-10-01 |
Other References:
LANIER MARION ET AL.: "Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure", ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 3, 8 February 2017 (2017-02-08), pages 316 - 320, XP055537904
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
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