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Patent Searching and Data


Title:
ISOQUINOLIN AND NAPHTHYDRIN COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2018/157277
Kind Code:
A1
Abstract:
The present invention provides a compound of Formula (I), where in X is selected from the group consisting of CH and N; Q is selected from the group consisting of CH3 and H; R is selected from the group consisting of (II) and (III), or a pharmaceutically acceptable salt thereof, compositions, methods to treat liver disease and NASH.

Inventors:
LEI, Hui (Indianapolis, Indiana, 46206-6288, US)
LIU, Gang (Indianapolis, Indiana, 46206-6288, US)
TIAN, Yuan (Indianapolis, Indiana, 46206-6288, US)
ZHANG, Haizhen (Indianapolis, Indiana, 46206-6288, US)
Application Number:
CN2017/075121
Publication Date:
September 07, 2018
Filing Date:
February 28, 2017
Export Citation:
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Assignee:
ELI LILLY AND COMPANY (Lilly Corporate Center, Indianapolis, Indiana, 46285, US)
LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD. (780 Cailun Road, Rm. 819 Zhangjiang High Technology Park, Pudong New Area, Shanghai 3, 201203, CN)
International Classes:
C07D453/06; A61K31/4196; A61P31/12; A61P37/02; C07D471/02
Foreign References:
CN104080771A2014-10-01
Other References:
LANIER MARION ET AL.: "Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure", ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 3, 8 February 2017 (2017-02-08), pages 316 - 320, XP055537904
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (22/F, Great Eagle Center 23 Harbour Road, Wanchai, Hong Kong, Kong, CN)
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