Title:
ISOQUINOLINONE AND QUINAZOLINONE COMPOUNDS, AND COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/051495
Kind Code:
A1
Abstract:
The present invention relates to isoquinolinone and quinazolinone compounds as represented by formula (I) or (II), a pharmaceutical composition containing the compounds, and the use of the compounds and the pharmaceutical composition thereof in the preparation of a drug for preventing, processing, treating and/or alleviating PI3-kinase-mediated diseases, disorders and/or conditions, or for inhibiting a PI3-kinase activity. The compounds show an excellent inhibitory activity and kinase selectivity for a target kinase, and have good pharmacokinetic properties and higher bioavailability.
Inventors:
WU SHUANG (CN)
SUN MINGMING (CN)
XU SHIMIN (CN)
XI NING (US)
SUN MINGMING (CN)
XU SHIMIN (CN)
XI NING (US)
Application Number:
PCT/CN2022/121567
Publication Date:
April 06, 2023
Filing Date:
September 27, 2022
Export Citation:
Assignee:
ZHONGSHAN INNOVATION BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07D487/04; A61K31/519; A61P11/00; A61P11/06; A61P19/00; A61P29/00; A61P35/00; A61P35/02; A61P37/00; C07D403/14; C07D417/14; C07D471/04
Domestic Patent References:
| WO2021004421A1 | 2021-01-14 | |||
| WO2019228404A1 | 2019-12-05 |
Foreign References:
| CN105793255A | 2016-07-20 | |||
| US20190202835A1 | 2019-07-04 | |||
| US20190135833A1 | 2019-05-09 | |||
| US20160122365A1 | 2016-05-05 |
Attorney, Agent or Firm:
HUIP PATENT ATTORNEYS (CN)
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