Title:
ISOXAZOLINE DERIVATIVES AS P, N LIGANDS
Document Type and Number:
WIPO Patent Application WO/2003/014133
Kind Code:
A1
Abstract:
The invention relates to novelligands of the phosphanylbenzothiophenyl-dihydroisoxazoline, phosphanyl-dihydrooxazolyl-indole and phosphanyl-dihydrooxazolyl-benzofuran type, especially compounds of formula (I) and mixtures of such compounds, wherein X is oxygen, sulfur, selenium or NO, wherein a is unsubstituted or substituted aryl, or alkyl or substituted alkyl and to processes for their preparation, to novel precursors and intermediates, to complexes with the said ligands, to their preparation and to their use as catalysts in organic synthesis (especially asymmetric organic synthesis).
Inventors:
END NICOLE (CH)
STOESSEL CATHERINE (FR)
BERENS ULRICH (DE)
COZZI PIER GIORGIO (IT)
STOESSEL CATHERINE (FR)
BERENS ULRICH (DE)
COZZI PIER GIORGIO (IT)
Application Number:
PCT/EP2002/008588
Publication Date:
February 20, 2003
Filing Date:
August 01, 2002
Export Citation:
Assignee:
CIBA SC HOLDING AG (CH)
END NICOLE (CH)
STOESSEL CATHERINE (FR)
BERENS ULRICH (DE)
COZZI PIER GIORGIO (IT)
END NICOLE (CH)
STOESSEL CATHERINE (FR)
BERENS ULRICH (DE)
COZZI PIER GIORGIO (IT)
International Classes:
B01J31/30; C07B53/00; C07B61/00; C07D413/04; C07C27/08; C07C29/143; C07C33/22; C07C45/29; C07C49/08; C07F9/6558; C07F15/00; C07F15/04; C07F15/06; (IPC1-7): C07F9/6558; C07F15/00; C07D413/04
Domestic Patent References:
| WO2000006556A1 | 2000-02-10 |
Foreign References:
| EP0780157A1 | 1997-06-25 | |||
| DE4243030A1 | 1994-06-23 | |||
| US5140034A | 1992-08-18 |
Other References:
HELMCHEN G ET AL: "Phosphinooxazolines-A new class of versatile, modular P,N-ligands for asymmetric catalysis", ACCOUNTS OF CHEMICAL RESEARCH, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 33, no. 6, 2000, pages 336 - 345, XP002185943, ISSN: 0001-4842
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1981, KELAREV ET AL.: "Preparation of 2-substituted ...", XP002224477, Database accession no. 1981:569050
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1994, KELAREV ET AL.: "Synthesis of azoles and diazoles...", XP002224478, Database accession no. 1994:77192
F.Y. KWONG; K.S. CHAN, ORGANOMETALLICS, vol. 20, 2001, pages 2570 - 2578
G. HELMCHEN; A. PFALTZ, ACC. CHEM. RES., vol. 33, 2000, pages 336
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1981, KELAREV ET AL.: "Preparation of 2-substituted ...", XP002224477, Database accession no. 1981:569050
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1994, KELAREV ET AL.: "Synthesis of azoles and diazoles...", XP002224478, Database accession no. 1994:77192
F.Y. KWONG; K.S. CHAN, ORGANOMETALLICS, vol. 20, 2001, pages 2570 - 2578
G. HELMCHEN; A. PFALTZ, ACC. CHEM. RES., vol. 33, 2000, pages 336
Attorney, Agent or Firm:
CIBA SPECIALTY CHEMICALS HOLDING INC. (Klybeckstrasse 141 Basel, CH)
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