Title:
ITACONIC ACID AND ITACONATE METHYLESTER AND DIMETHYLESTER PRODUCTION
Document Type and Number:
WIPO Patent Application WO/2015/181310
Kind Code:
A3
Abstract:
The present invention relates to a recombinant yeast cell which is capable of producing one or more of 4-methyl itaconate, 1-methyl itaconate or 1,4-dimethyl itaconate. The invention also relates to a recombinant yeast cell which is capable of producing itaconic acid and which overexpresses: - a nucleic acid encoding a polypeptide having cis-aconitate decarboxylase activity; and - a nucleic acid encoding a polypeptide which catalyzes a reaction towards acetyl CoA. These recombinant yeast cells may be used in processes for the production of itaconic acid, 4-methyl itaconate, 1-methyl itaconate or 1,4-dimethyl itaconate.
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Inventors:
ZHAO ZHENG (NL)
MEIJRINK BERNARD (NL)
HOEVEN VAN DER ROBERTUS ANTONIUS MIJNDERT (NL)
WU LIANG (NL)
ROUBOS JOHANNES ANDRIES (NL)
MEIJRINK BERNARD (NL)
HOEVEN VAN DER ROBERTUS ANTONIUS MIJNDERT (NL)
WU LIANG (NL)
ROUBOS JOHANNES ANDRIES (NL)
Application Number:
PCT/EP2015/061882
Publication Date:
February 18, 2016
Filing Date:
May 28, 2015
Export Citation:
Assignee:
DSM IP ASSETS BV (NL)
International Classes:
C12P1/00; C12N15/63
Domestic Patent References:
| WO2014080024A2 | 2014-05-30 | |||
| WO2013076280A1 | 2013-05-30 | |||
| WO2009104958A1 | 2009-08-27 |
Foreign References:
| US20100285546A1 | 2010-11-11 |
Other References:
DER: ""Itaconate production by Ustilago maydis; the influence of genes and cultivation conditions"", 10 October 2013 (2013-10-10), XP055202557, Retrieved from the Internet [retrieved on 20150715]
Attorney, Agent or Firm:
MONACO, Vania (P.O. Box 4, AA Echt, NL)
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