JLP CYTOPLASMIC SCAFFOLDING PROTEIN AND NUCLEIC ACIDS ENCODING IT

Title:

JLP CYTOPLASMIC SCAFFOLDING PROTEIN AND NUCLEIC ACIDS ENCODING IT

Document Type and Number:

WIPO Patent Application WO2003066652

Kind Code:

A8

Abstract:

A cytoplasmic scaffolding protein named JLP has been isolated, which tethers MEKK3, MKK4, JNK,p38 MAPK, C-Myc and MAX into a sign aling module that controls the apoptotic response. Nucleic acid sequences which encode JLP, and methods of using the JLP nucleic acids and proteins, and mutants thereof, to modulate the apoptotic response in cells are provided.

Inventors:

LEE CLEMENT M (US)
DHANASEKARAN N (US)
REDDY PREMKUMAR E (US)

Application Number:

PCT/US2003/003355

Publication Date:

February 19, 2004

Filing Date:

February 04, 2003

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Assignee:

UNIV TEMPLE (US)
LEE CLEMENT M (US)
DHANASEKARAN N (US)
REDDY PREMKUMAR E (US)

International Classes:

C07K14/47; (IPC1-7): C07H21/04; A01N61/00; C12N15/87

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