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Document Type and Number:
WIPO Patent Application WO/2018/195439
Kind Code:
Provided herein, inter alia, are methods and compounds for modulating K-Ras treating cancer.

MCCORMICK, Frank (5 Bernice St, San Francisco, CA, 94103, US)
RENSLO, Adam (5359 Shafter Avenue, Oakland, CA, 94618, US)
TURNER, David (501 Prospect Blvd, Apt. 24CFrederick, MD, 21701, US)
MACIAG, Anna, E. (9214 Charterhouse Rd, Frederick, MD, 21704, US)
DYBA, Marcin (1930 Moran Drive, Frederick, MD, 21702-6443, US)
VO, Elizabeth, D. (391 Valencia St, Apt. 302San Francisco, CA, 94103, US)
SAAVEDRA, Joseph (7189 Browns Ln, Thurmont, MD, 21788, US)
KUMARI, Vandana (9159 Bealls Farm Road, Frederick, MD, 21704, US)
Application Number:
Publication Date:
November 29, 2018
Filing Date:
April 20, 2018
Export Citation:
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1111 Franklin Street, 12th FloorOakland, CA, 94607-5200, US)
LEIDOS BIOMEDICAL RESEARCH, INC. (P.O. Box B, 1050 Boyles StreetFrederick, MD, 21702, US)
International Classes:
C07D405/14; A61K31/4192; C07C233/76; C07D207/40; C07D213/40; C07D231/56; C07D237/08; C07D239/26; C07D241/12; C07D303/36; C07D305/06; C07D307/28; C07D403/06; C07D403/14; C07D405/12
Domestic Patent References:
Foreign References:
Other References:
SHAIK SIDDIQ PASHA ET AL: "Design and synthesis of imidazo[2,1-b]thiazole linked triazole conjugates: Microtubule-destabilizing agents", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 126, 20 September 2016 (2016-09-20), pages 36 - 51, XP029885607, ISSN: 0223-5234, DOI: 10.1016/J.EJMECH.2016.09.060
YUANXIANG WANG ET AL: "Targeting Mutant KRAS for Anticancer Therapeutics: A Review of Novel Small Molecule Modulators", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 13, 23 April 2013 (2013-04-23), pages 5219 - 5230, XP055458688, ISSN: 0022-2623, DOI: 10.1021/jm3017706
BRIAN R DE COSTA ET AL: "Synthesis and Biological Evaluation of Conformationally Restricted 2-( l-Pyrrolidinyl)-N-[2-( 3,4-dichlorophenyl)ethyl]-N-met hylethylenediamines as c Receptor Ligands. 1. Pyrrolidine, Piperidine, Homopiperidine, and Tetrahydroisoquinoline Classes", J. MED. CHEM, 1 January 1992 (1992-01-01), pages 4334 - 4343, XP055105017, Retrieved from the Internet [retrieved on 20140303]
WINTER E. ET AL.: "Structure-Activity Relationships of Chromone Derivatives toward the Mechanism of Interaction with and Inhibition of Breast Cancer Resistance Protein ABCG2", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 24, 2013, pages 9849 - 9860, XP002784593, DOI: 10.1021/jm401649j
PRUET, J. ET AL.: "Optimized 5-Membered Heterocycle-Linked Pterins for the Inhibition of Ricin Toxin A", ACS MEDICINAL CHEMISTRY LETTERS, vol. 3, no. 7, 2012, XP002784594
HARKALA, KARNA JI; EPPAKAYALA, LAXMINARAYANA; MARINGANTI, THIRUMALA CHARY: "Synthesis and biological evaluation of benzimidazole-linked 1,2,3-triazole congeners as agents", ORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 14, 2014, pages 1 - 4, XP002784646, DOI: :10.1186/s13588-014-0014-x
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; IDDON, BRIAN ET AL: "Azoles. Part 13. Synthesis and bromine .fwdarw. lithium exchange reactions of some 1-substituted 4,5-dibromo-1H-1,2,3-triazoles and 2-substituted 4,5-dibromo-2H-1,2,3-triazoles", XP002784647, retrieved from STN Database accession no. 1996:387369
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TOME, A. C.: "Product class 13: 1,2,3-triazoles", XP002784648, retrieved from STN Database accession no. 2004:204626
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DURUST, YASAR ET AL: "Synthesis of novel triazoles bearing 1,2,4-oxadiazole and phenylsulfonyl groups by 1,3-dipolar cycloaddition of some organic azides and their biological activities", XP002784649, retrieved from STN Database accession no. 2014:1868483
Attorney, Agent or Firm:
TERRANOVA, Zachary, L. et al. (Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.One Financial Cente, Boston MA, 02111, US)
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