Title:
K-RAS MUTANT PROTEIN INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2024/041621
Kind Code:
A1
Abstract:
The invention provides K-Ras mutant protein inhibitors of formula (Ⅰ), a composition containing the same and the use thereof.
Inventors:
YANG HONGWEI (CN)
MA CUNBO (CN)
WANG PENG (CN)
GAO PANLIANG (CN)
HAN HUIFENG (CN)
LI RUNZE (CN)
LIU DAN (CN)
WANG YANPING (CN)
LONG WEI (CN)
MA CUNBO (CN)
WANG PENG (CN)
GAO PANLIANG (CN)
HAN HUIFENG (CN)
LI RUNZE (CN)
LIU DAN (CN)
WANG YANPING (CN)
LONG WEI (CN)
Application Number:
PCT/CN2023/114824
Publication Date:
February 29, 2024
Filing Date:
August 25, 2023
Export Citation:
Assignee:
JACOBIO PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D519/00; A61K31/551; A61P35/00; C07D471/16; C07D491/22
Domestic Patent References:
| WO2018206539A1 | 2018-11-15 | |||
| WO2019215203A1 | 2019-11-14 | |||
| WO2022173678A1 | 2022-08-18 | |||
| WO2021093758A1 | 2021-05-20 | |||
| WO2022047260A1 | 2022-03-03 |
Foreign References:
| CN112745335A | 2021-05-04 | |||
| CN112300194A | 2021-02-02 | |||
| CN112390818A | 2021-02-23 |
Other References:
KETTLE JASON G., BAGAL SHARAN K., BICKERTON SUE, BODNARCHUK MICHAEL S., BOYD SCOTT, BREED JASON, CARBAJO RODRIGO J., CASSAR DOYLE : "Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 65, no. 9, 12 May 2022 (2022-05-12), US , pages 6940 - 6952, XP093143553, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.2c00369
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