KCNQ2-5 CHANNEL ACTIVATOR - ONO PHARMACEUTICAL CO

Title:

KCNQ2-5 CHANNEL ACTIVATOR

Document Type and Number:

WIPO Patent Application WO/2016/063990

Kind Code:

A1

Abstract:

The present invention relates to a compound represented by general formula (1). (The definition of each group in the formula is as described in the specification.) The compound is useful as a prophylactic and/or therapeutic agent for KCNQ2-5 channel-associated diseases.

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Inventors:

YASHIRO KENTARO (JP)
WAKAMATSU DAISUKE (JP)
SAITO TETSUJI (JP)

Application Number:

PCT/JP2015/080034

Publication Date:

April 28, 2016

Filing Date:

October 23, 2015

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Assignee:

ONO PHARMACEUTICAL CO (JP)

International Classes:

C07C275/32; A61K31/17; A61K31/341; A61K31/351; A61K31/381; A61K31/4045; A61K31/417; A61K31/422; A61K31/4245; A61K31/426; A61K31/435; A61K31/4545; A61K31/4965; A61K31/505; A61P7/10; A61P7/12; A61P13/10; A61P43/00; C07C233/26; C07C233/29; C07C275/40; C07D209/30; C07D213/40; C07D213/61; C07D213/74; C07D233/64; C07D239/26; C07D241/12; C07D271/06; C07D277/28; C07D307/52; C07D309/04; C07D333/20; C07D333/28; C07D413/06

Domestic Patent References:

WO2011085351A2

2011-07-14

Foreign References:

JP2008512402A	2008-04-24
JP2003192660A	2003-07-09
JP2014521616A	2014-08-28
JPS5182239A	1976-07-19

Other References:

YU ,H. ET AL.: "Discovery, Synthesis, and Structure-Activity Relationship of a Series of N-Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener", ACS CHEMICAL NEUROSCIENCE, vol. 2, no. 10, 2011, pages 572 - 577, XP055275425, ISSN: 1948-7193
See also references of EP 3210969A4

Attorney, Agent or Firm:

AOKI, Atsushi et al. (Toranomon 37 Mori Bldg. 5-1, Toranomon 3-chome, Minato-k, Tokyo 23, JP)

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