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Title:
KETONE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX
Document Type and Number:
WIPO Patent Application WO2004005478
Kind Code:
A3
Abstract:
This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The ligands comprise a class of ketones.

Inventors:
TICE COLIN M (US)
MICHELOTTI ENRIQUE L (US)
HORMANN ROBERT E (US)
Application Number:
US0321149W
Publication Date:
April 01, 2004
Filing Date:
July 05, 2003
Export Citation:
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Assignee:
RHEOGENE, INC
TICE, COLIN, M.
MICHELOTTI, ENRIQUE, L.
HORMANN, ROBERT, E.
International Classes:
C12N15/09; A61K31/166; A61K31/343; A61K31/351; A61K31/357; A61K31/36; A61K31/382; A61K31/44; A61K31/4409; A61K31/445; A61K31/4468; A61K31/519; A61K48/00; A61P43/00; C07C233/31; C07C233/76; C07C235/46; C07C235/48; C07C235/50; C07C235/54; C07C237/32; C07C271/20; C07C275/24; C07C311/20; C07C311/29; C07D207/14; C07D211/56; C07D211/58; C07D213/40; C07D307/85; C07D309/14; C07D317/54; C07D317/58; C07D317/68; C07D317/72; C07D319/08; C07D319/18; C07D321/08; C07D335/02; C07D487/04; C07F9/36; C07K14/705; C07K14/72; C12P21/02; C12Q1/68; (IPC1-7): C07C49/04; C07C49/20; C07C49/527; C07C69/00; C07C225/02; C07C229/02; C07C237/00; A61K31/12; A61K31/16; A61K31/18
Foreign References:
US4971993A1990-11-20
EP0405537A11991-01-02
Other References:
See also references of EP 1534658A4
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