Title:
KETOSTEROID C27-MONOOXYGENASE DERIVED FROM MYCOBACTERIUM NEOAURUM AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/028006
Kind Code:
A1
Abstract:
Provided are a mycobacterium neoaurum, a ketosteroid C27-monooxygenase derived from mycobacterium neoaurum, and application of the ketosteroid C27-monooxygenase. By adding expressions of SMO isoenzyme SMO1, SMO2 and/or SMO3 to mycobacterium neoaurum of high-yield androstenedione (ADD),the final yield of the ADD can be effectively improved.
Inventors:
RAO ZHIMING (CN)
SHAO MINGLONG (CN)
ZHANG XIAN (CN)
YANG TAOWEI (CN)
XU MEIJUAN (CN)
SHAO MINGLONG (CN)
ZHANG XIAN (CN)
YANG TAOWEI (CN)
XU MEIJUAN (CN)
Application Number:
PCT/CN2016/097110
Publication Date:
February 15, 2018
Filing Date:
August 29, 2016
Export Citation:
Assignee:
UNIV JIANGNAN (CN)
International Classes:
C12N1/21; C12N15/53; C12N15/67; C12P33/16; C12R1/32
Foreign References:
| CN104830888A | 2015-08-12 | |||
| CN103382445A | 2013-11-06 | |||
| CN1639354A | 2005-07-13 | |||
| JPS60133884A | 1985-07-17 |
Other References:
DATABASE Protein 19 February 2015 (2015-02-19), "MULTISPECIES: cytochrome P450 steroid C27-monooxygenase [Mycobacterium]", XP055604120, retrieved from NCBI Database accession no. WP_019510071.1
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO.,LTD. (CN)
Download PDF: