Title:
A KEY INTERMEDIATE FOR PREPARING GLUCOPYRANOSYL DERIVATIVES AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/012568
Kind Code:
A1
Abstract:
The invention relates to a key intermediate for preparing glucopyranosyl derivatives and preparation method thereof, the glucopyranosyl derivatives are sodium-dependent glucose transporter (SGLT) inhibitors. Specifically, the key intermediate has stable properties, less impurities, and high optical purity (diastereoselectivity); the reagents used in the preparation method are cheap, the reaction conditions are mild, and there is no need to use silica gel column chromatography for purification and the post-treatment is simple, the purification is easy, the equipment requirements are low, the production cost is low, and the process is safer and more controllable, and suitable for industrial production.
Inventors:
RUAN SAI (CN)
PENG FEI (CN)
YUAN WEIHUI (CN)
LI ZHENG (CN)
ZHANG ZONGYUAN (CN)
WU WUYONG (CN)
LIAO JUNXU (CN)
GU ZHENG (CN)
PENG FEI (CN)
YUAN WEIHUI (CN)
LI ZHENG (CN)
ZHANG ZONGYUAN (CN)
WU WUYONG (CN)
LIAO JUNXU (CN)
GU ZHENG (CN)
Application Number:
PCT/CN2023/107451
Publication Date:
January 18, 2024
Filing Date:
July 14, 2023
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07D295/205; C07D295/185
Domestic Patent References:
| WO2020143653A1 | 2020-07-16 | |||
| WO2014159151A1 | 2014-10-02 |
Foreign References:
| CN113912567A | 2022-01-11 | |||
| CN104513283A | 2015-04-15 |
Other References:
PAUL BOWLES, STEVEN J. BRENEK, STEPHANE CARON, NGA M. DO, MICHELE T. DREXLER, SHENGQUAN DUAN, PASCAL DUBé, ERIC C. HANSEN, BR: "Commercial Route Research and Development for SGLT2 Inhibitor Candidate Ertugliflozin", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 18, no. 1, 17 January 2014 (2014-01-17), US , pages 66 - 81, XP055283061, ISSN: 1083-6160, DOI: 10.1021/op4002802
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