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Title:
KIDNEY DISEASE PROGNOSIS PREDICTION METHOD AND SYSTEM
Document Type and Number:
WIPO Patent Application WO/2017/200024
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.

Inventors:
ISAKA YOSHITAKA (JP)
KIMURA TOMONORI (JP)
YASUDA KEIKO (JP)
HAMASE KENJI (JP)
MITA MASASHI (JP)
Application Number:
PCT/JP2017/018591
Publication Date:
November 23, 2017
Filing Date:
May 17, 2017
Export Citation:
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Assignee:
UNIV OSAKA (JP)
UNIV KYUSHU NAT UNIV CORP (JP)
SHISEIDO CO LTD (JP)
International Classes:
G01N33/68; G01N33/48; G01N33/72
Foreign References:
JP2015132598A2015-07-23
JP2013224929A2013-10-31
JP2015535936A2015-12-17
US20060160236A12006-07-20
Other References:
HIRONORI ISHIDA: "Serum D-Amino Acid Elucidated in Renal Failure", KITASATO MEDICINE, vol. 23, no. l, February 1993 (1993-02-01), pages 51 - 62, XP9512768
YOSHIYUKI MURATA: "Study on prediction method for CKD stages by LC/MS", J TOXICOL SCI, vol. 39, July 2014 (2014-07-01), pages S346, XP009514734
FUMIO HOSHI: "Adenine Toyo ni yoru Neko no Mansei Jinfuzen Sakushutsu to sono Kessho Yuri Amino San Nodo", JAPANESE SOCIETY OF VETERIANY SCIENCE GAKUJUTSU SHUKAI KOEN YOSHISHU, vol. 125 th, March 1998 (1998-03-01), pages 278, XP009516810, ISSN: 1347-8621
MASAO KANAUCHI: "Diagnostic Significance Of Arginine Loading Test In The Early Stage Of Diabetic Nephropathy", J NARA MED ASSOC, vol. 42, no. 3, June 1991 (1991-06-01), pages 221 - 225, XP055582614
SUN JINCHUN: "Serum metabolomic profiles from patients with acute kidney injury: A pilot study", J CHROMATOGR B, vol. 893 -894, 15 April 2012 (2012-04-15), pages 107 - 113, XP055262565
See also references of EP 3460477A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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