Title:
KIDNEY REGENERATION ACCELERATOR AND PRODUCTION METHOD FOR SAME
Document Type and Number:
WIPO Patent Application WO/2021/145425
Kind Code:
A1
Abstract:
A kidney regeneration accelerator that contains a component obtained by decellularizing a mammalian organ. A production method for a kidney regeneration accelerator that involves decellularizing a mammalian organ to obtain a component that includes an extracellular matrix, freeze drying and then pulverizing the component to obtain a powder, and performing a sterilization treatment on the powder. A pharmaceutical composition for use in treating kidney disease that contains a component obtained by decellularizing a mammalian organ. A treatment mehod for kidney disease that involves applying a pharmaceutical composition that contains a component obtained by decellularizing a mammalian organ to a site to be treated on the kidney of a human or animal kidney disease patient.
Inventors:
YAGI HIROSHI (JP)
KUSHIGE HIROKO (JP)
KURODA KOHEI (JP)
SATO AKIKO (JP)
HAMADA KENICHI (JP)
AMANO YUKI (JP)
KUSHIGE HIROKO (JP)
KURODA KOHEI (JP)
SATO AKIKO (JP)
HAMADA KENICHI (JP)
AMANO YUKI (JP)
Application Number:
PCT/JP2021/001241
Publication Date:
July 22, 2021
Filing Date:
January 15, 2021
Export Citation:
Assignee:
UNIV KEIO (JP)
JSR CORP (JP)
JSR CORP (JP)
International Classes:
A61K35/407; A61K9/08; A61K9/10; A61K9/14; A61K9/19; A61K35/22; A61K35/37; A61K35/38; A61K35/39; A61K35/42; A61K35/44; A61L27/36; A61L27/38; A61P13/12
Domestic Patent References:
| WO2017136786A1 | 2017-08-10 |
Foreign References:
| JP2015160039A | 2015-09-07 |
Other References:
O'NEILL JOHN D; FREYTES DONALD O; ANANDAPPA ANNABELLE J; OLIVER JUAN A; VUNJAK-NOVAKOVIC GORDANA: "The regulation of growth and metabolism of kidney stem cells with regional specificity using extracellular matrix derived from kidney", BIOMATERIALS, vol. 34, no. 38, 26 September 2013 (2013-09-26), pages 9830 - 9841, XP028735917, DOI: 10.1016/j.biomaterials.2013.09.022
SU JIMMY, SATCHELL SIMON C., SHAH RAMILLE N., WERTHEIM JASON A.: "Kidney decellularized extracellular matrix hydrogels: Rheological characterization and human glomerular endothelial cell response to encapsulation", J BIOMED MATER RES, vol. 106, no. 9, September 2018 (2018-09-01), pages 2448 - 2462, XP055842573
NAGAO RYAN J., XU JIN, LUO PING, XUE JUN, WANG YI, KOTHA SURYA, ZENG WEN, FU XIAOYUN, HIMMELFARB JONATHAN, ZHENG YING: "Decellularized Human Kidney Cortex Hydrogels Enhance Kidney Microvascular Endothelial Cell Maturation and Quiescence", TISSUE ENGINEERING, vol. 22, no. 19-20, 1 October 2016 (2016-10-01), pages 1140 - 1150, XP055842569
ZHOU CHANGCHENG; ZHOU LIUHUA; LIU JINGYU; XU LUWEI; XU ZHENG; CHEN ZAOZAO; GE YUZHENG; ZHAO FENG; WU RAN; WANG XINNING; JIANG NAN;: "Kidney extracellular matrix hydrogel enhances therapeutic potential of adipose-derived mesenchymal stem cells for renal ischemia reperfusion injury", ACTA BIOMATERIALIA, vol. 115, 6 August 2020 (2020-08-06), pages 250 - 263, XP086270733, DOI: 10.1016/j.actbio.2020.07.056
SU JIMMY, SATCHELL SIMON C., SHAH RAMILLE N., WERTHEIM JASON A.: "Kidney decellularized extracellular matrix hydrogels: Rheological characterization and human glomerular endothelial cell response to encapsulation", J BIOMED MATER RES, vol. 106, no. 9, September 2018 (2018-09-01), pages 2448 - 2462, XP055842573
NAGAO RYAN J., XU JIN, LUO PING, XUE JUN, WANG YI, KOTHA SURYA, ZENG WEN, FU XIAOYUN, HIMMELFARB JONATHAN, ZHENG YING: "Decellularized Human Kidney Cortex Hydrogels Enhance Kidney Microvascular Endothelial Cell Maturation and Quiescence", TISSUE ENGINEERING, vol. 22, no. 19-20, 1 October 2016 (2016-10-01), pages 1140 - 1150, XP055842569
ZHOU CHANGCHENG; ZHOU LIUHUA; LIU JINGYU; XU LUWEI; XU ZHENG; CHEN ZAOZAO; GE YUZHENG; ZHAO FENG; WU RAN; WANG XINNING; JIANG NAN;: "Kidney extracellular matrix hydrogel enhances therapeutic potential of adipose-derived mesenchymal stem cells for renal ischemia reperfusion injury", ACTA BIOMATERIALIA, vol. 115, 6 August 2020 (2020-08-06), pages 250 - 263, XP086270733, DOI: 10.1016/j.actbio.2020.07.056
Attorney, Agent or Firm:
MATSUNUMA Yasushi et al. (JP)
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