Title:
KIF18A INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/032661
Kind Code:
A1
Abstract:
The present invention relates to the technical field of medicine, in particular to a KIF18A inhibitor compound, a pharmaceutically acceptable salt thereof, an ester thereof or a stereoisomer thereof, a pharmaceutical composition and preparation comprising the compound, the pharmaceutically acceptable salt thereof, the ester thereof or the stereoisomer thereof, a method for preparing the compound, the pharmaceutically acceptable salt thereof, the ester thereof or the stereoisomer thereof, and the use of the compound, the pharmaceutically acceptable salt thereof, the ester thereof or the stereoisomer thereof in the preparation of a drug for treating and/or preventing diseases mediated by KIF18A and related diseases.
Inventors:
LIU BIN (CN)
CHEN BO (CN)
CHEN BO (CN)
Application Number:
PCT/CN2023/112020
Publication Date:
February 15, 2024
Filing Date:
August 09, 2023
Export Citation:
Assignee:
SHANDONG XUANZHU PHARMA CO LTD (CN)
International Classes:
C07D487/04; A61K31/41; A61K31/438; A61P35/00; C07D401/14; C07D471/04
Domestic Patent References:
| WO2021007378A1 | 2021-01-14 |
Foreign References:
| US20210292332A1 | 2021-09-23 | |||
| CN108530378A | 2018-09-14 | |||
| CN113226473A | 2021-08-06 | |||
| CN114302880A | 2022-04-08 |
Other References:
AKHILA METTU ET AL.: "Mechanistic investigations on substituted benzene sulphonamides as apoptosis inducing anticancer agents", BIOORGANIC CHEMISTRY, vol. 95, 23 December 2019 (2019-12-23), XP086005415, DOI: 10.1016/j.bioorg.2019.103539
Download PDF: