Title:
KILLER CELL CAPABLE OF EFFICIENTLY AND STABLY EXPRESSING ANTIBODY, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/219934
Kind Code:
A1
Abstract:
Provided is a transgenic killer cell. A genome of the transgenic killer cell stably integrates a coding sequence comprising an antibody of a human Fc section, or an expression cassette of a coding sequence comprising a chimeric antigen receptor or an inhibitory or activated antibody, and an inverted terminal repeat, two ends of which comprise transposons. Also provided are a pharmaceutical composition comprising the transgenic killer cell, and uses thereof.
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Inventors:
QIAN QIJUN (CN)
JIN HUAJUN (CN)
XU JIEYING (CN)
LI LINFANG (CN)
YE ZHENLONG (CN)
HE ZHOU (CN)
CUI LIANZHEN (CN)
WU HONGPING (CN)
JIN HUAJUN (CN)
XU JIEYING (CN)
LI LINFANG (CN)
YE ZHENLONG (CN)
HE ZHOU (CN)
CUI LIANZHEN (CN)
WU HONGPING (CN)
Application Number:
PCT/CN2017/088955
Publication Date:
December 28, 2017
Filing Date:
June 19, 2017
Export Citation:
Assignee:
SHANGHAI CELL THERAPY RES INST (CN)
SHANGHAI ENGINEERING RES CENTER FOR CELL THERAPY GROUP CO LTD (CN)
SHANGHAI ENGINEERING RES CENTER FOR CELL THERAPY GROUP CO LTD (CN)
International Classes:
C12N5/10; A61K35/17; A61K48/00; A61P35/00; C12N15/13; C12N15/85
Foreign References:
CN105154473A | 2015-12-16 | |||
CN105331585A | 2016-02-17 | |||
CN105330750A | 2016-02-17 |
Other References:
ZHANG, XINWEI ET AL.: "Clinical Research Status of PD-1 Blocking Antibody in the Treatment of Tumour", MEDICINE AND PHILOSOPHY, vol. 36, no. 2B, 28 February 2015 (2015-02-28), ISSN: 1002-0772
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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