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Patent Searching and Data


Title:
KILLER CELL CAPABLE OF EFFICIENTLY AND STABLY EXPRESSING ANTIBODY, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/219934
Kind Code:
A1
Abstract:
Provided is a transgenic killer cell. A genome of the transgenic killer cell stably integrates a coding sequence comprising an antibody of a human Fc section, or an expression cassette of a coding sequence comprising a chimeric antigen receptor or an inhibitory or activated antibody, and an inverted terminal repeat, two ends of which comprise transposons. Also provided are a pharmaceutical composition comprising the transgenic killer cell, and uses thereof.

Inventors:
QIAN QIJUN (CN)
JIN HUAJUN (CN)
XU JIEYING (CN)
LI LINFANG (CN)
YE ZHENLONG (CN)
HE ZHOU (CN)
CUI LIANZHEN (CN)
WU HONGPING (CN)
Application Number:
PCT/CN2017/088955
Publication Date:
December 28, 2017
Filing Date:
June 19, 2017
Export Citation:
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Assignee:
SHANGHAI CELL THERAPY RES INST (CN)
SHANGHAI ENGINEERING RES CENTER FOR CELL THERAPY GROUP CO LTD (CN)
International Classes:
C12N5/10; A61K35/17; A61K48/00; A61P35/00; C12N15/13; C12N15/85
Foreign References:
CN105154473A2015-12-16
CN105331585A2016-02-17
CN105330750A2016-02-17
Other References:
ZHANG, XINWEI ET AL.: "Clinical Research Status of PD-1 Blocking Antibody in the Treatment of Tumour", MEDICINE AND PHILOSOPHY, vol. 36, no. 2B, 28 February 2015 (2015-02-28), ISSN: 1002-0772
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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