Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
KINASE INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2005/118543
Kind Code:
A1
Abstract:
A compound represented by the general formula (I): [wherein A represents optionally substituted amino or a group represented by the formula (II) (wherein ring A1 represents an optionally substituted nitrogenous heterocyclic group); D represents optionally substituted C1-4 alkylene; and E represents optionally protected hydroxy or optionally substituted amino]; a salt or solvate of the compound; or a prodrug of any of these. These compounds have inhibitory activity against kinases, especially c-Jun N-terminal kinase, and are hence useful as a preventive and/or therapeutic agent for metabolic diseases such as diabetes (type I diabetes, type II diabetes (insulin-resistant diabetes and diabetes caused by insulin secretion deficiency)) and hyperlipemia and inflammatory diseases such as chronic rheumatoid arthritis.

Inventors:
YOSHIZAWA TOSHIO (JP)
OHMOTO KAZUYUKI (JP)
OGAWA KOJI (JP)
Application Number:
PCT/JP2005/010120
Publication Date:
December 15, 2005
Filing Date:
June 02, 2005
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
ONO PHARMACEUTICAL CO (JP)
YOSHIZAWA TOSHIO (JP)
OHMOTO KAZUYUKI (JP)
OGAWA KOJI (JP)
International Classes:
A61K31/4155; A61K31/473; A61K31/495; A61K31/496; A61K31/505; A61K31/5377; A61K45/00; A61P1/04; A61P1/18; A61P3/00; A61P3/06; A61P3/10; A61P7/04; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P21/04; A61P25/14; A61P27/06; A61P29/00; A61P35/00; A61P37/00; A61P37/06; A61P43/00; C07D213/74; C07D213/82; C07D221/08; C07D231/38; C07D239/90; C07D263/34; C07D295/08; C07D405/12; C07D409/12; C07D487/06; C07D495/04; (IPC1-7): C07D213/74; A61K31/4155; A61K31/473; A61K31/495; A61K31/496; A61K31/505; A61K31/5377; A61K45/00; A61P1/04; A61P1/18; A61P3/00; A61P3/06; A61P3/10; A61P7/04; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P21/04; A61P25/14; A61P27/06; A61P29/00; A61P35/00; A61P37/00; A61P37/06; A61P43/00; C07D213/82; C07D221/08; C07D231/38; C07D239/90; C07D263/34; C07D295/08; C07D405/12; C07D409/12; C07D487/06; C07D495/04
Domestic Patent References:
WO2002046184A12002-06-13
WO2002046170A22002-06-13
WO2003068754A12003-08-21
WO2003106455A12003-12-24
WO2003091249A12003-11-06
WO2002092573A22002-11-21
WO2005034869A22005-04-21
WO2004052880A12004-06-24
WO2003004488A12003-01-16
WO2003033483A12003-04-24
WO2002051442A12002-07-04
WO2003015608A22003-02-27
WO2002057261A22002-07-25
WO2003070726A12003-08-28
WO2005018624A22005-03-03
WO2005037197A22005-04-28
WO2005021519A22005-03-10
WO2004080980A12004-09-23
WO2004080973A12004-09-23
WO2004065370A12004-08-05
WO2004013130A12004-02-12
WO2004110375A22004-12-23
WO2003072062A22003-09-04
WO2004056823A12004-07-08
Foreign References:
JP2003137785A2003-05-14
JP2003510319A2003-03-18
JP2004161716A2004-06-10
JP2003528857A2003-09-30
JP2003523340A2003-08-05
JP2003176273A2003-06-24
JP2002516854A2002-06-11
JP2003517447A2003-05-27
US20040087626A12004-05-06
JP2003525278A2003-08-26
JP2003507329A2003-02-25
JP2003506375A2003-02-18
JPH05501248A1993-03-11
JPS61254563A1986-11-12
JPS50140469A1975-11-11
JPS62169768A1987-07-25
JP2004143099A2004-05-20
JPH11106398A1999-04-20
JP2004502760A2004-01-29
JPS56100765A1981-08-12
JP2003530819A2003-10-21
US6562944B12003-05-13
JPH06347846A1994-12-22
Other References:
RUECKLE T. ET AL.: "Design, Synthesis, and Biological Activity of Novel,Potent, and Selective (Benzoylaminomethyl) thiophene Sulfonamide Inhibitors of c-Jun-N-Terminal Kinase.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 27, 30 December 2004 (2004-12-30), pages 6921 - 6934, XP002991319
REGAN J. ET AL.: "Pyrazole Urea-Based Inhibitors of p38 MAP Kinase: From Lead Compound to Clinical Candidate.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 45, no. 14, 2002, pages 2994 - 3008, XP002243050
ROLLAND-FULCRAND V. ET AL.: "Efficient chemoenzymatic synthesis of enantiomerically pure bera-heterocyclic amino acid derivatives.", ASYMMETRY, vol. 11, no. 23, 2000, pages 4719 - 4724, XP004313846
LIU J. ET AL.: "Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation.", MOLECULAR CANCER THERAPEUTICS., vol. 3, no. 6, 1 June 2004 (2004-06-01), pages 709 - 714, XP002991320
THUNUS L. ET AL.: "Synthesis and pharmacological properties of some 2,5-substituted isopropyl and hydroxyethylpipereranylpyridines.", ANNALES PHARMACEUTIQUES FRANCAISES., vol. 35, no. 5-6, 1977, pages 197 - 204, XP002991321
THUNUS L. ET AL.: "Synthesis and pharmacological properties ofsome hydroxyethylpiperazinylpyridines (2,3 and 3,4 substitutions).", ANNALES PHARMACEUTIQUES FRANCAISES,, vol. 33, no. 12, 1975, pages 663 - 669, XP002991322
AKHUNDOV R. ET AL.: "Synthesis and psychotropic activity of the amides of 2-aminonicotinic acid.", KHIMIKO-FARMATSEVTICHESKII, vol. 20, no. 1, 1986, pages 48 - 50, XP002991323
FILITIS L. ET AL.: "Tetrahydrocarbazole derivatives and their antitubercular activity in vitro. I. N-Substituted hexahydro-1H-pyrazino [3,2,1-j,k] carbazoles.", KHIMIKO-FARMATSEVTICHESKII ZHURNAL., vol. 20, no. 3, 1986, pages 300 - 303, XP002991324
POGOSYAN A. ET AL.: "Preparation and polymerization of 2-(1-pyrazolyl)ethylacrylamides.", ARMYANSKII KHIMICHESKII ZHURNAL., vol. 38, no. 8, 1985, pages 518 - 520, XP002991325
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: HETEROCYCLIC COMPOUNDS AND THEIR USE AS ALDOSTERONE SYNTHASE INHIBITORS

Next Patent: CYCLOALKYL SUBSTITUTED PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES