Title:
KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2012/121168
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a novel compound having an excellent CK2-inhibiting activity and high safety; and use applications of the compound. Provided are: a CK2 inhibitor comprising, as an active ingredient, a compound represented by formula (I) (wherein the ring A represents a 5-membered nitrogenated heterocyclic ring; the ring B represents a saturated/unsaturated hydrocarbon ring or a saturated/unsaturated heterocyclic ring; R1 represents a hydrogen atom, an alkyl group, an aryl group which may be substituted, or an acyl group; R2 represents a carboxyl group, a methylenecarboxyl group or a nitro group; and n represents an integer of 1 to 3), a salt of the compound, or a prodrug of the compound or the salt: and others.
Inventors:
TSUJIMOTO GOZOH (JP)
HIRASAWA AKIRA (JP)
MURATA KATSUMI (JP)
FUJII NOBUTAKA (JP)
OHNO HIROAKI (JP)
OISHI SHINYA (JP)
SUZUKI YAMATO (JP)
ZENGYE HOU (JP)
NAKANISHI ISAO (JP)
KINOSHITA TAKAYOSHI (JP)
TAKAKURA YOSHINOBU (JP)
NISHIKAWA MAKIYA (JP)
HIRASAWA AKIRA (JP)
MURATA KATSUMI (JP)
FUJII NOBUTAKA (JP)
OHNO HIROAKI (JP)
OISHI SHINYA (JP)
SUZUKI YAMATO (JP)
ZENGYE HOU (JP)
NAKANISHI ISAO (JP)
KINOSHITA TAKAYOSHI (JP)
TAKAKURA YOSHINOBU (JP)
NISHIKAWA MAKIYA (JP)
Application Number:
PCT/JP2012/055451
Publication Date:
September 13, 2012
Filing Date:
March 02, 2012
Export Citation:
Assignee:
UNIV KYOTO (JP)
UNIV KINKI (JP)
UNIV OSAKA PREFECT PUBLIC CORP (JP)
TSUJIMOTO GOZOH (JP)
HIRASAWA AKIRA (JP)
MURATA KATSUMI (JP)
FUJII NOBUTAKA (JP)
OHNO HIROAKI (JP)
OISHI SHINYA (JP)
SUZUKI YAMATO (JP)
ZENGYE HOU (JP)
NAKANISHI ISAO (JP)
KINOSHITA TAKAYOSHI (JP)
TAKAKURA YOSHINOBU (JP)
NISHIKAWA MAKIYA (JP)
UNIV KINKI (JP)
UNIV OSAKA PREFECT PUBLIC CORP (JP)
TSUJIMOTO GOZOH (JP)
HIRASAWA AKIRA (JP)
MURATA KATSUMI (JP)
FUJII NOBUTAKA (JP)
OHNO HIROAKI (JP)
OISHI SHINYA (JP)
SUZUKI YAMATO (JP)
ZENGYE HOU (JP)
NAKANISHI ISAO (JP)
KINOSHITA TAKAYOSHI (JP)
TAKAKURA YOSHINOBU (JP)
NISHIKAWA MAKIYA (JP)
International Classes:
C07D231/40; A61K31/415; A61K31/416; A61K31/4245; A61K31/426; A61K31/433; A61K31/4439; A61P13/12; A61P35/00; A61P43/00; C07D231/56; C07D271/10; C07D277/20; C07D277/44; C07D285/135; C07D409/04; C07D417/12
Domestic Patent References:
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Other References:
KHANFAR, MOHAMMAD A. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, 2010, pages 8534 - 8545
HOU, ZENGYE ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 6, 2012, pages 2899 - 2903
HOU, ZENGYE ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 6, 2012, pages 2899 - 2903
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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Claims: