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Title:
PI3K/MTOR KINASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2010/056320
Kind Code:
A3
Abstract:
6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidine and 2-morpholin-4-yl-7H- pyrrolo[2,3-d]pyrimidine derivatives have unexpected drug properties as inhibitors of PI3 and/or mTOR kinases and are useful in treating disorders related to abnormal PI3K/mT0R activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.

Inventors:
LIANG CONGXIN (US)
LI ZHIGANG (CN)
Application Number:
PCT/US2009/006071
Publication Date:
September 16, 2010
Filing Date:
November 11, 2009
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Assignee:
TYROGENEX INC (US)
LIANG CONGXIN (US)
LI ZHIGANG (CN)
International Classes:
C07D413/04; A61K31/519; A61K31/5375; A61P35/00; C07D265/30; C07D403/14; C07D407/14; C07D413/02; C07D487/02; C07D487/04
Foreign References:
US20080234262A12008-09-25
US20080039459A12008-02-14
US5502187A1996-03-26
Other References:
KNIGHT,Z.A. ET AL.: "Chemically targeting the PI3K family", BIOCHEMICAL SOCIETY TRANSACTION, vol. 35, no. 2, 2007, pages 245 - 249, XP008132314
Attorney, Agent or Firm:
HSI, Jeffrey, D. et al. (P.O. Box 55874Boston, MA, US)
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