Title:
KINASE SUBSTRATE
Document Type and Number:
WIPO Patent Application WO/2018/207760
Kind Code:
A1
Abstract:
In order to provide a polypeptide which can specifically and with high sensitivity be phosphorylated by kinases, and to provide a kinase substrate kit with which the kinome can be more accurately analyzed, provided is a polypeptide comprising an amino acid sequence from (a) or (b), (a) an amino acid sequence represented by any of SEQ ID NOS. 1-187 and 249-251 and (b) an amino acid sequence represented by any of SEQ ID NOS. 1-187 and 249-251 in which at least one amino acid has been replaced, deleted, added or inserted, the polypeptide exhibiting at least double the reactivity to a target kinase than to other kinases.
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Inventors:
ISHIHAMA YASUSHI (JP)
SUGIYAMA NAOYUKI (JP)
SAKAMOTO DAI (JP)
SUGIYAMA NAOYUKI (JP)
SAKAMOTO DAI (JP)
Application Number:
PCT/JP2018/017726
Publication Date:
November 15, 2018
Filing Date:
May 08, 2018
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C07K7/06; C07K7/08; C12Q1/48; G01N33/15; G01N33/50; G01N33/53; G01N37/00
Domestic Patent References:
| WO2016004233A2 | 2016-01-07 |
Foreign References:
| JP2007236388A | 2007-09-20 | |||
| JP2016523236A | 2016-08-08 | |||
| JP2014514566A | 2014-06-19 |
Other References:
KANG, JH. ET AL.: "Phosphorylation of Rho- associated kinase (Rho-kinase/ROCK/ROK) substrates by protein kinases A and C", BIOCHIMIE, vol. 89, no. 1, 2007, pages 39 - 47, XP005813447
IMAMURA, H. ET AL.: "Identifications of Putative PKA Substrates with Quantitative Phosphoproteomics and Primary-Sequence-Based Scoring", J PROTEOME RES, vol. 16, no. 4, 13 March 2017 (2017-03-13), pages 1825 - 1830, XP055561663
SUGIYAMA, N. ET AL.: "Large-scale profiling of protein kinases for cellular signaling studies by mass spectrometry and other techniques", J PHARM BIOMED ANAL, vol. 130, 2016, pages 264 - 272, XP029761140
IMAMURA, H. ET AL.: "Identifications of Putative PKA Substrates with Quantitative Phosphoproteomics and Primary-Sequence-Based Scoring", J PROTEOME RES, vol. 16, no. 4, 13 March 2017 (2017-03-13), pages 1825 - 1830, XP055561663
SUGIYAMA, N. ET AL.: "Large-scale profiling of protein kinases for cellular signaling studies by mass spectrometry and other techniques", J PHARM BIOMED ANAL, vol. 130, 2016, pages 264 - 272, XP029761140
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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