Title:
KIT FOR DETECTING PROSTATE CANCER AND USE THEREOF, AND KIT FOR DETECTING BLADDER CANCER AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/061281
Kind Code:
A1
Abstract:
A kit for detecting prostate cancer and the use thereof, and a kit for detecting bladder cancer and the use thereof. The kit for detecting prostate cancer comprises sarcosine oxidase, metal nanoparticles, a gold nanomaterial, and a reagent for etching the gold nanomaterial. The concentration of sarcosine in urine is evaluated by means of a chromogenic reaction, and the concentration of sarcosine is distinguished by means of color. Therefore, visual detection of prostate cancer by the naked eye is realized. The kit for detecting prostate cancer is non-invasive, low-cost, convenient to use and on-site responsive, and is suitable for popularization and application in the diagnosis of prostate cancer.
Inventors:
YAN ZEJUN (CN)
HUANG YOUJU (CN)
ZHANG DONG (CN)
CHENG YUE (CN)
LI MING (CN)
RUAN LIEMIN (CN)
HUANG YOUJU (CN)
ZHANG DONG (CN)
CHENG YUE (CN)
LI MING (CN)
RUAN LIEMIN (CN)
Application Number:
PCT/CN2023/120095
Publication Date:
March 28, 2024
Filing Date:
September 20, 2023
Export Citation:
Assignee:
THE FIRST AFFILIATED HOSPITAL OF NINGBO UNIV (CN)
International Classes:
C12Q1/6886; B22F9/24; C12N15/11; C12Q1/26; C12Q1/68; G01N21/64; G01N21/78; G01N33/543; G01N33/574
Foreign References:
| CN108031859A | 2018-05-15 | |||
| CN114136958A | 2022-03-04 | |||
| US20160222432A1 | 2016-08-04 | |||
| US20180364249A1 | 2018-12-20 |
Other References:
LAN, JIANMING ET AL.: "Colorimetric Determination of Sarcosine in Urine Samples of Prostatic Carcinoma by Mimic Enzyme Palladium Nanoparticles", ANALYTICA CHIMICA ACTA, vol. 825, 31 March 2014 (2014-03-31), XP028648852, DOI: 10.1016/j.aca.2014.03.040
ZHONG, QINGMEI ET AL.: "Colorimetric Determination of Sarcosine in Human Urine with Enzyme-like Reaction Mediated Au Nanorods Etching", MICROCHEMICAL JOURNAL, vol. 165, 27 February 2021 (2021-02-27), XP086553946, DOI: 10.1016/j.microc.2021.106120
BIN ZHOU, CHEN YAO; HU XIJIANG: "Determination of Trace Sarcosine Based on Aptamer-Gold Nanoparticles", JOURNAL OF ANALYTICAL SCIENCE, vol. 38, no. 2, 15 April 2022 (2022-04-15), pages 219 - 223, XP093149638
ZHONG, QINGMEI ET AL.: "Colorimetric Determination of Sarcosine in Human Urine with Enzyme-like Reaction Mediated Au Nanorods Etching", MICROCHEMICAL JOURNAL, vol. 165, 27 February 2021 (2021-02-27), XP086553946, DOI: 10.1016/j.microc.2021.106120
BIN ZHOU, CHEN YAO; HU XIJIANG: "Determination of Trace Sarcosine Based on Aptamer-Gold Nanoparticles", JOURNAL OF ANALYTICAL SCIENCE, vol. 38, no. 2, 15 April 2022 (2022-04-15), pages 219 - 223, XP093149638
Attorney, Agent or Firm:
NINGBO COIPOR INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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