Title:
KIT FOR DIAGNOSING COLORECTAL CANCER AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF COLORECTAL CANCER
Document Type and Number:
WIPO Patent Application WO/2012/011777
Kind Code:
A2
Abstract:
The present invention relates to: a composition for diagnosing colorectal cancer containing a formulation for measuring the expression level of a chromosome 1 open reading frame 135 (C1orf135) gene mRNA or the protein thereof; a kit for diagnosing colorectal cancer containing the composition; a method for providing information on diagnosis of colorectal cancer, the method comprising a step for measuring the expression level of a C1orf135 gene mRNA or the expression level of the protein coded by the gene; a pharmaceutical composition for the prevention or the treatment of colorectal cancer, the composition comprising an expression inhibitor for a C1orf135 gene or an activity inhibitor for the protein thereof; and a method for screening a therapeutic agent for colorectal cancer. The present invention enables the accurate diagnosis of colorectal cancer by providing a gene specific to colorectal cancer, and a diagnostic marker for determining the metastasis and prognosis of colorectal cancer, and can be useful in the diagnosis and prognosis management of colorectal cancer. Also, the present invention enables the development of new bio-medicines having fewer side effects and customized anticancer drugs by providing a colorectal cancer-specific therapeutic agent capable of inhibiting the gene.
Inventors:
CHUNG, Kyung Sook (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
정경숙 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
WON, Mi Sun (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
원미선 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
KIM, Young Joo (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
김영주 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
SONG, Eun Young (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
송은영 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
정경숙 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
WON, Mi Sun (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
원미선 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
KIM, Young Joo (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
김영주 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
SONG, Eun Young (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
송은영 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
Application Number:
KR2011/005431
Publication Date:
January 26, 2012
Filing Date:
July 22, 2011
Export Citation:
Assignee:
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
한국생명공학연구원 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
CHUNG, Kyung Sook (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
정경숙 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
WON, Mi Sun (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
원미선 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
KIM, Young Joo (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
김영주 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
SONG, Eun Young (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
한국생명공학연구원 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
CHUNG, Kyung Sook (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
정경숙 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
WON, Mi Sun (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
원미선 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
KIM, Young Joo (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
김영주 (대전광역시 유성구 어은동 52번지, 305-806 Daejeon, 305-806, KR)
SONG, Eun Young (52 Eoeun-dong, Yuseong-gu, Daejeon 305-806, 305-806, KR)
International Classes:
C12Q1/68; A61P35/00; C12N15/12; G01N33/574
Attorney, Agent or Firm:
SON, Min (Hanol Intellectual Property & Law, 6th Floor City Air Tower,159-9 Samseong-dong, Gangnam-gu, Seoul 135-973, 135-973, KR)
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