Title:
KITS AND METHODS FOR EVALUATING, SELECTING AND CHARACTERIZING TISSUE CULTURE MODELS USING MICRO-RNA PROFILES
Document Type and Number:
WIPO Patent Application WO/2014/153471
Kind Code:
A3
Abstract:
A method for identifying a cluster or sub-cluster of microRNAs (miRNAs) that provides a signature profile for differentiating cells grown in one type of culture model from cells grown in another type of culture model. Also, kits and methods for evaluating, selecting, and/or characterizing tissue culture models using the miRNA profiles and a cluster or sub-cluster of miRNAs that provides the signature profile. Also, a method for identifying a putative mRNA target of a miRNA for evaluating and targeting with a drug candidate by using the cluster or sub-cluster of miRNAs and a method for selecting a culture model for use as a drug platform for screening a candidate molecule for activity against tumor cells in tumor stroma.
Inventors:
ARUNACHALAM PADMA (US)
Application Number:
PCT/US2014/031362
Publication Date:
December 31, 2014
Filing Date:
March 20, 2014
Export Citation:
Assignee:
ARUNACHALAM PADMA (US)
International Classes:
A61K48/00; G16B25/10; G16B40/30
Domestic Patent References:
| WO2009108856A2 | 2009-09-03 | |||
| WO2012115885A1 | 2012-08-30 | |||
| WO2012138691A2 | 2012-10-11 |
Foreign References:
| US20120041683A1 | 2012-02-16 |
Other References:
See also references of EP 2976110A4
Attorney, Agent or Firm:
MASS, Clifford J. et al. (1040 Avenue of the AmericasNew York, New York, US)
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