Title:
KLK5 INHIBITORY PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2020/095921
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel peptide. This peptide contains the amino acid sequence represented by sequence number 61, and inhibits protease.
Inventors:
NISHIMIYA DAISUKE (JP)
YANO HIDENORI (JP)
TAKAHASHI HIDENORI (JP)
YAMAGUCHI SHINJI (JP)
OFUCHI SHIHO (JP)
YANO HIDENORI (JP)
TAKAHASHI HIDENORI (JP)
YAMAGUCHI SHINJI (JP)
OFUCHI SHIHO (JP)
Application Number:
PCT/JP2019/043384
Publication Date:
May 14, 2020
Filing Date:
November 06, 2019
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
A61K45/00; A61K35/12; A61K38/57; A61K47/64; A61K47/65; A61K47/68; A61K48/00; A61P1/04; A61P11/06; A61P17/00; A61P17/02; A61P17/06; A61P17/16; A61P25/00; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C07K14/81; C07K16/00; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/63; C12P21/02; C12Q1/37; G01N33/15; G01N33/50; G01N33/53; C12N9/64
Domestic Patent References:
| WO2018117244A1 | 2018-06-28 | |||
| WO2014024914A1 | 2014-02-13 | |||
| WO2019049933A1 | 2019-03-14 | |||
| WO2014024914A1 | 2014-02-13 |
Other References:
CHEN, T. ET AL.: "Identification of trypsin- inhibitory site and structure determination of human SP1NK2 serine proteinase inhibitor", PROTEINS, vol. 77, 2009, pages 209 - 219, XP055502505, DOI: 10.1002/prot.22432
KANTYKA, T. ET AL.: "Inhibition of kallikrein- related petidases by the serine protease inhibitor of Kazal-type 6.", PEPTIEEDS, vol. 32, 2011, pages 1187 - 1192, XP028372893, DOI: 10.1016/j.peptides.2011.03.009
NISHIMIYA, D. ET AL.: "A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases", SCIENTIFIC REPORTS, vol. 9, no. 11436, 7 August 2019 (2019-08-07), pages 1 - 11, XP055707463, DOI: 10.1038/s41598-019-47615-5
OVAERE P ET AL., TRENDS BIOCHEM SCI., vol. 34, no. 9, 2009, pages 453 - 463
DESCARGUES P ET AL., NAT GENET., vol. 37, no. 1, 2005, pages 56 - 65
RATTENHOLL A ET AL., DRUG NEWS PERSPECT., vol. 21, no. 7, 2008, pages 369 - 381
HOVNANIAN A., CELL TISSUE RES., vol. 351, no. 2, 2013, pages 289 - 300
SARRI CA ET AL., MOL DIAGN THER, vol. 21, no. 2, 2017, pages 137 - 152
FURIO L ET AL., PLOS GENET., vol. 11, no. 9, 2015, pages e1005389
KASPAREK P ET AL., PLOS GENET., vol. 13, no. 1, 2017, pages e1006566
FURIO L ET AL., J EXP MED., vol. 211, no. 3, 2014, pages 499 - 513
YAMASAKI K ET AL., NAT MED., vol. 13, no. 8, 2007, pages 975 - 980
NISHIO Y ET AL., GENES IMMUN., vol. 4, no. 7, 2003, pages 515 - 517
KUSUNOKI T ET AL., J ALLERGY CLIN IMMUNOL., vol. 4, no. 7, 2005, pages 515 - 517
LAN CC ET AL., EXP DERMATOL., vol. 20, no. 12, 2011, pages 975 - 979
KATO A ET AL., BR J DERMATOL., vol. 148, no. 4, 2003, pages 665 - 669
ZHAO LP ET AL., J EUR ACAD DERMATOL VENEREOL., vol. 26, no. 5, 2012, pages 572 - 577
FORTUGNO P ET AL., HUM MOL GENET., vol. 21, no. 19, 2012, pages 4187 - 4200
CHEN T ET AL., PROTEINS., vol. 77, no. 1, 2009, pages 209 - 219
L. LEHNINGER: "Biochemistry", 1975, WORTH PUBLISHER, pages: 73 - 75
MICHAELIS L ET AL., BIOCHEMISTRY, vol. 50, no. 39, 2011, pages 8264 - 8269
MORRISON JF, BIOCHIM BIOPHYS ACTA, vol. 185, no. 2, 1969, pages 269 - 286
COUSSENS, LM ET AL., SCIENCE, vol. 295, no. 5564, 2002, pages 2387 - 2392
BISSETT, D ET AL., J.CLIN.ONCOL., vol. 23, no. 4, 2005, pages 842 - 849
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
SMITH ET AL., J. MOL. BIOL., vol. 147, 1981, pages 195 - 197
FRANCISCO, J. A. ET AL., PROC. NATL. ACAD. SCI., vol. 90, 1993, pages 10444 - 10448
BODER, E. T. ET AL., NAT. BIOTECHNOL., vol. 15, 1997, pages 553 - 557
HO M ET AL., METHODS MOL BIOL., vol. 525, 2009, pages 337 - 352
SMITH, G. P., SCIENCE, vol. 228, 1985, pages 1315 - 1317
MATTHEAKIS LC ET AL., PROC. NATL. ACAD. SCI., vol. 91, no. 19, 1994, pages 9022 - 9029
NEMOTO N ET AL., FEBS LETT., vol. 414, no. 2, 1997, pages 405 - 408
PINI, A. ET AL., COMB. CHEM. HIGH THROUGHPUT SCREEN., vol. 5, 2002, pages 503 - 510
UEDA, M.TANAKA, A., BIOTECHNOL. ADV., vol. 18, 2000, pages 121
UEDA, M.TANAKA, A., J. BIOSCI. BIOENG., vol. 90, 2000, pages 125
FURIO, L. ET AL., PLOS. GENET., vol. 11, 2015, pages e1005389
FORTUGNO, P. ET AL., HUM. MOL. GENET., vol. 21, 2012, pages 4187 - 4200
YAMASAKI, K. ET AL., NAT. MED., vol. 13, 2007, pages 975 - 980
NIN, M. ET AL., J. DERMATOL. SCI., vol. 54, 2009, pages 17 - 24
KOMATSU, N. ET AL., BR. J. DERMATOL., vol. 156, 2007, pages 875 - 883
GRUNBERG, M. ET AL., EUR. J. IMMUNOL., vol. 48, 2018, pages 1592 - 1594
RADULOVIC, M. ET AL., J. NEUROPATHOL. EXP. NEUROL., vol. 72, 2013, pages 1072 - 1089
EMAMI, N. ET AL., MOL. ONCOL., vol. 1, 2007, pages 269 - 287
DESCARGUES, P. ET AL., NAT. GENET., vol. 37, 2004, pages 56 - 65
PETROVA, E. ET AL., 8TH INTERNATIONAL SYMPOSIUM ON KALLIKREINS AND KALLIKREIN-RELATED PEPTIDASES: ABSTRACT BOOK, 2019, pages 28
SAMBROOK, J.FRITSCH, E. F.MANIATIS, T.: "Molecular Cloning", 1982, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3892301A4
KANTYKA, T. ET AL.: "Inhibition of kallikrein- related petidases by the serine protease inhibitor of Kazal-type 6.", PEPTIEEDS, vol. 32, 2011, pages 1187 - 1192, XP028372893, DOI: 10.1016/j.peptides.2011.03.009
NISHIMIYA, D. ET AL.: "A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases", SCIENTIFIC REPORTS, vol. 9, no. 11436, 7 August 2019 (2019-08-07), pages 1 - 11, XP055707463, DOI: 10.1038/s41598-019-47615-5
OVAERE P ET AL., TRENDS BIOCHEM SCI., vol. 34, no. 9, 2009, pages 453 - 463
DESCARGUES P ET AL., NAT GENET., vol. 37, no. 1, 2005, pages 56 - 65
RATTENHOLL A ET AL., DRUG NEWS PERSPECT., vol. 21, no. 7, 2008, pages 369 - 381
HOVNANIAN A., CELL TISSUE RES., vol. 351, no. 2, 2013, pages 289 - 300
SARRI CA ET AL., MOL DIAGN THER, vol. 21, no. 2, 2017, pages 137 - 152
FURIO L ET AL., PLOS GENET., vol. 11, no. 9, 2015, pages e1005389
KASPAREK P ET AL., PLOS GENET., vol. 13, no. 1, 2017, pages e1006566
FURIO L ET AL., J EXP MED., vol. 211, no. 3, 2014, pages 499 - 513
YAMASAKI K ET AL., NAT MED., vol. 13, no. 8, 2007, pages 975 - 980
NISHIO Y ET AL., GENES IMMUN., vol. 4, no. 7, 2003, pages 515 - 517
KUSUNOKI T ET AL., J ALLERGY CLIN IMMUNOL., vol. 4, no. 7, 2005, pages 515 - 517
LAN CC ET AL., EXP DERMATOL., vol. 20, no. 12, 2011, pages 975 - 979
KATO A ET AL., BR J DERMATOL., vol. 148, no. 4, 2003, pages 665 - 669
ZHAO LP ET AL., J EUR ACAD DERMATOL VENEREOL., vol. 26, no. 5, 2012, pages 572 - 577
FORTUGNO P ET AL., HUM MOL GENET., vol. 21, no. 19, 2012, pages 4187 - 4200
CHEN T ET AL., PROTEINS., vol. 77, no. 1, 2009, pages 209 - 219
L. LEHNINGER: "Biochemistry", 1975, WORTH PUBLISHER, pages: 73 - 75
MICHAELIS L ET AL., BIOCHEMISTRY, vol. 50, no. 39, 2011, pages 8264 - 8269
MORRISON JF, BIOCHIM BIOPHYS ACTA, vol. 185, no. 2, 1969, pages 269 - 286
COUSSENS, LM ET AL., SCIENCE, vol. 295, no. 5564, 2002, pages 2387 - 2392
BISSETT, D ET AL., J.CLIN.ONCOL., vol. 23, no. 4, 2005, pages 842 - 849
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
SMITH ET AL., J. MOL. BIOL., vol. 147, 1981, pages 195 - 197
FRANCISCO, J. A. ET AL., PROC. NATL. ACAD. SCI., vol. 90, 1993, pages 10444 - 10448
BODER, E. T. ET AL., NAT. BIOTECHNOL., vol. 15, 1997, pages 553 - 557
HO M ET AL., METHODS MOL BIOL., vol. 525, 2009, pages 337 - 352
SMITH, G. P., SCIENCE, vol. 228, 1985, pages 1315 - 1317
MATTHEAKIS LC ET AL., PROC. NATL. ACAD. SCI., vol. 91, no. 19, 1994, pages 9022 - 9029
NEMOTO N ET AL., FEBS LETT., vol. 414, no. 2, 1997, pages 405 - 408
PINI, A. ET AL., COMB. CHEM. HIGH THROUGHPUT SCREEN., vol. 5, 2002, pages 503 - 510
UEDA, M.TANAKA, A., BIOTECHNOL. ADV., vol. 18, 2000, pages 121
UEDA, M.TANAKA, A., J. BIOSCI. BIOENG., vol. 90, 2000, pages 125
FURIO, L. ET AL., PLOS. GENET., vol. 11, 2015, pages e1005389
FORTUGNO, P. ET AL., HUM. MOL. GENET., vol. 21, 2012, pages 4187 - 4200
YAMASAKI, K. ET AL., NAT. MED., vol. 13, 2007, pages 975 - 980
NIN, M. ET AL., J. DERMATOL. SCI., vol. 54, 2009, pages 17 - 24
KOMATSU, N. ET AL., BR. J. DERMATOL., vol. 156, 2007, pages 875 - 883
GRUNBERG, M. ET AL., EUR. J. IMMUNOL., vol. 48, 2018, pages 1592 - 1594
RADULOVIC, M. ET AL., J. NEUROPATHOL. EXP. NEUROL., vol. 72, 2013, pages 1072 - 1089
EMAMI, N. ET AL., MOL. ONCOL., vol. 1, 2007, pages 269 - 287
DESCARGUES, P. ET AL., NAT. GENET., vol. 37, 2004, pages 56 - 65
PETROVA, E. ET AL., 8TH INTERNATIONAL SYMPOSIUM ON KALLIKREINS AND KALLIKREIN-RELATED PEPTIDASES: ABSTRACT BOOK, 2019, pages 28
SAMBROOK, J.FRITSCH, E. F.MANIATIS, T.: "Molecular Cloning", 1982, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3892301A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
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