KRAS G12C INHIBITORS ENCOMPASSING A PIPERAZINE RING AND USE THEREOF IN THE TREATMENT OF CANCER

Title:

KRAS G12C INHIBITORS ENCOMPASSING A PIPERAZINE RING AND USE THEREOF IN THE TREATMENT OF CANCER

Document Type and Number:

WIPO Patent Application WO/2020/050890

Kind Code:

A3

Abstract:

Provided herein are KRAS G12C inhibitors, such as [Insert Compound Here] composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

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Inventors:

ALLEN JOHN GORDON (US)
LANMAN BRIAN ALAN (US)
CHEN JIAN (US)
REED ANTHONY B (US)
CEE VICTOR J (US)
LIU LONGBIN (US)
LOPEZ PATRICIA (US)
WURZ RYAN PAUL (US)
NGUYEN THOMAS T (US)
BOOKER SHON (US)
ALLEN JENNIFER REBECCA (US)
CHU-MOYER MARGARET (US)
AMEGADZIE ALBERT (US)
CHEN NING (US)
GOODMAN CLIFFORD (US)
LOW JONATHAN D (US)
MA VU VAN (US)
MINATTI ANA ELENA (US)
NISHIMURA NOBUKO (US)
PICKRELL ALEXANDER J (US)
WANG HUI-LING (US)
SHIN YOUNGSOOK (US)
SIEGMUND AARON C (US)
YANG KEVIN C (US)
TAMAYO NURIA A (US)
WALTON MARY (US)
XUE QIUFEN (US)

Application Number:

PCT/US2019/036626

Publication Date:

June 25, 2020

Filing Date:

June 11, 2019

Export Citation:

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Assignee:

AMGEN INC (US)

International Classes:

C07D471/04; A61K31/519; A61K31/551; A61K45/06; A61P35/00; C07D487/04

Domestic Patent References:

WO2015054572A1	2015-04-16
WO2017201161A1	2017-11-23
WO2019051291A1	2019-03-14
WO2018217651A1	2018-11-29
WO2019213516A1	2019-11-07
WO2019241157A1	2019-12-19

Other References:

KM MORRISSEY ET AL: "Immunotherapy and Novel Combinations in Oncology: Current Landscape, Challenges, and Opportunities : Immunotherapy and Novel Combinations in Oncology", CLINICAL AND TRANSLATIONAL SCIENCE - CTS, vol. 9, no. 2, 30 March 2016 (2016-03-30), US, pages 89 - 104, XP055415286, ISSN: 1752-8054, DOI: 10.1111/cts.12391

Attorney, Agent or Firm:

REIDY, Joseph F. (US)

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