Title:
KRAS G12D INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/274383
Kind Code:
A1
Abstract:
A KRAS inhibitor compound represented by formula (I), and an isomer or a pharmaceutically acceptable salt thereof. The compound represented by formula (I) and the composition thereof can effectively treat diseases related to KRAS mutation.
Inventors:
WANG FENG (CN)
WANG JINGLU (CN)
ZHANG CHUANXIU (CN)
ZHOU FENG (CN)
ZHANG MAN (CN)
GAO DAXIN (CN)
WANG JINGLU (CN)
ZHANG CHUANXIU (CN)
ZHOU FENG (CN)
ZHANG MAN (CN)
GAO DAXIN (CN)
Application Number:
PCT/CN2022/103056
Publication Date:
January 05, 2023
Filing Date:
June 30, 2022
Export Citation:
Assignee:
SHANGHAI DE NOVO PHARMATECH CO LTD (CN)
International Classes:
C07D498/22; A61K31/553; A61P35/00; C07D519/00
Domestic Patent References:
| WO2022173678A1 | 2022-08-18 | |||
| WO2019179515A1 | 2019-09-26 |
Foreign References:
| CN112074520A | 2020-12-11 | |||
| CN112745335A | 2021-05-04 | |||
| CN110603258A | 2019-12-20 | |||
| CN202110752493A | 2021-07-02 | |||
| CN202110873254A | 2021-07-30 | |||
| CN202111062878A | 2021-09-10 | |||
| CN202111398357A | 2021-11-19 | |||
| CN202210042057A | 2022-01-14 | |||
| CN202210675157A | 2022-06-15 |
Other References:
JONATHAN ET AL., NATURE REVIEWS, vol. 15, 2016, pages 771 - 785
ZENKER ET AL., J MED GENET, vol. 44, 2007, pages 131 - 135
CANCER DISCOVERY, vol. 7, no. 8, 2017, pages 818 - 831
"McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC
BERGE ET AL.: "Pharmaceutically acceptable salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
ZENKER ET AL., J MED GENET, vol. 44, 2007, pages 131 - 135
CANCER DISCOVERY, vol. 7, no. 8, 2017, pages 818 - 831
"McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC
BERGE ET AL.: "Pharmaceutically acceptable salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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