INTERNATIONAL SEARCH REPORT Int tional Application No PCT/DK 00/00225 C. (Continuation) DOCUMENTS CONSIDERED TO BE RELEVANT Category Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No. X SINGH S K ET AL :"Synthesis of 1-62 2'-Amino-LNA : A Novel Conformationally Restricted High-Affinity Oligonucleotide Analogue with a Handle" J. ORG. CHEM., vol. 63,1998, pages 10035-10039, XP002901184 the whole document X OBIKA S ET AL:"Stability and structural 1-62 features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2'-0, 4'-C-methyleneribonucleosides" TETRAHEDRON LETTERS, vol. 39,1998, pages 5401-5404, XP002901185 the whole document X KOSHKIN A A ET AL :"LNA (Locked Nucleic 1-62 Acid): An RNA Mimic Forming Exceedingly Stable LNA: LNA Duplexes" J. AM. CHEM. SOC., vol. 120,1998, pages 13252-13253, XP002901186 the whole document X SINGH S K ET AL :"LNA (Locked Nucleic 1-62 Acids): synthesis and high-affinity nucleic acid recognition" CHEM. COMMUN., 1998, pages 455-456, XP002901187 the whole document X WO 98 39352 A (IMANISHI TAKESHI) 1-34 11 September 1998 (1998-09-11) the whole document X OBIKA S ET AL :"Synthesis of 23-32 2'-0, 4'-C-Methyleneuridine and-cytidine. Novel Bicyclic Nucleosides Having a Fixed C3,-endo Sugar Puckering" TETRAHEDRON LETTERS, vol. 38, no. 50,1997, pages 8735-8738, XP002901188 the whole document X SINGH S K ET AL :"Synthesis of Novel 2-22, Bicyclo (2.2.1) Ribonucleosides : 2'-Amino-33-62 and 2'-Thio-LNA Monomeric Nucleosides" J. ORG. CHEM., vol. 63, 1998, pages 6078-6079, XP002901189 claims 1,23-32 3 3 INTERNATIONAL SEARCH REPORT Im.. ational Application No PCT/DK 00/00225 C. (Continuation) DOCUMENTS CONSIDERED TO BE RELEVANT Category Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No. X RAJWANSHI V K ET AL :"Synthesis and 2-22, restricted furanose conformations of three 33-62 novel bicyclic thymine nucleosides : a xylo-LNA nucleoside, a 3'-0,5'-C-methylene-linked nucleoside, and a 2'-0, 5'-C-methylene-linked nucleoside" J. CHEM. SOC. PERKIN TRANS., vol. 1,1999, pages 1407-1414, XP002901190 claims 1,23-32 X KOSHKIN A A ET AL :"Novel Convenient 1,23-32 Syntheses of LNA (2.2.1) Bicyclo Nucleosides" TETRAHEDRON LETTERS, vol. 39,1998, pages 4381-4384, XP002901191 the whole document A 2-22, 33-62 X KUMAR R ET AL :"The first analogues of 2-22, LNA (Locked Nucleic Acids): 33-62 phosphorothioate-LNA and 2'-Thio-LNA" BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 8,1998, pages 2219-2222, XP002901192 claims 1,23-32 3 International application No. INTERNATIONAL SEARCH REPORT PCT/DK 00/00225 Box I Observations where certain claims were found unsearchable (Continuation of item 1 of first sheet) This International Search Report has not been established in respect of certain claims under Article 17 (2) (a) for the following reasons: 1. Claims Nos.: because they relate to subject matter not required to be searched by this Authority, namely: 2. Claims Nos. : 1-62 because they relate to parts of the international Application that do not comply with the prescribed requirements to such an extent that no meaningful International Search can be carried out, specifically: see FURTHER INFORMATION sheet PCT/ISA/210 3. Claims Nos.: because they are dependent claims and are not drafted in accordance with the second and third sentences of Rule 6.4 (a). Box li Observations where unity of invention is lacking (Continuation of item 2 of first sheet) This International Searching Authority found multiple inventions in this international application, as follows: 1. As a ! i required additional search fees were timely paid by the applicant, this International Search Report covers all searchable claims. 2. As all searchable claims could be searched without effort justifying an additional fee, this Authority did not invite payment of any additional fee. 3. As only some of the required additional search fees were timely paid by the applicant, this International Search Report covers only those claims for which fees were paid, specifically claims Nos.: 4. No required additional search fees were timely paid by the applicant. Consequently, this International Search Report is restricted to the invention first mentioned in the claims; it is covered by claims Nos.: Remark on Protest g The additional search fees were accompanied by the applicant's protest. u No protest accompanied the payment of additional search fees. u FURTHER INFORMATION CONTINUED FROM PCT/ISA/210 Continuation of Box 1. 2 Claims Nos.: 1-62 Present claims 1-62 relate to an extremely large number of possible compounds. In fact, the claim contains so many options, variables, possible permutations and provisos that a lack of clarity I concisenness within the meaning of Article 6 PCT arises to such an extent as to render a meaningful search of the claims impossible.

Consequently, the search has been carried out for those parts of the application which appear to be clear and concise, namely the i recited in the examples.

The initial phase of the search revealed a very large number of documents relevant to the issue of novelty. So many documents were retrieved that it is impossible to determine which parts of the claim (s) may be said to define subject-matter for which protection might legitimately be sought (Article 6 PCT). For these reasons, a meaningful search over the whole breadth of the claim (s) is impossible. Consequently, the search has been restricted INTERNATIONAL SEARCH REPORT | ím.. ational Application No Information on patent family members Patent document Publication Patent family Publication cited in search report date member (s) date WO 9914226 A 25-03-1999 AU 9063398 A 05-04-1999 EP 1015469 A 05-07-2000 WO 9839352 A 11-09-1998 AU 720472 B 01-06-2000 AU 6120998 A 22-09-1998 EP 1013661 A 28-06-2000 JP 10304889 A 17-11-1998