Title:
LIVER CANCER IMAGING BY Fluciclovine
Document Type and Number:
WIPO Patent Application WO/2019/027033
Kind Code:
A1
Abstract:
Provided is an imaging agent of liver cancer or cancer that has occurred near the liver, the imaging agent containing radioactive trans-1-amino-3-fluorocyclobutane-1-carboxylic acid (fluciclovine) or a pharmacologically acceptable salt thereof as an active ingredient.
Inventors:
OKA SHUNTARO (JP)
SHIMAMOTO NAOTO (JP)
NAKAJIMA SHUICHI (JP)
SHIMAMOTO NAOTO (JP)
NAKAJIMA SHUICHI (JP)
Application Number:
PCT/JP2018/029177
Publication Date:
February 07, 2019
Filing Date:
August 03, 2018
Export Citation:
Assignee:
NIHON MEDIPHYSICS CO LTD (JP)
IBARAKI PREFECTURE (JP)
IBARAKI PREFECTURE (JP)
International Classes:
A61K51/04; A61K101/02
Domestic Patent References:
| WO2017051519A1 | 2017-03-30 |
Foreign References:
| US20170189565A1 | 2017-07-06 |
Other References:
SCHUSTER, D. M. ET AL.: "Anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid: physiologic uptake patterns, incidental findings, and variants that may simulate disease", THE JOURNAL OF NUCLEAR MEDICINE, vol. 55, no. 12, 2014, pages 1986 - 1992, XP055370559, DOI: 10.2967/jnumed.114.143628
ASANO, Y. ET AL.: "Phase I clinical study of NMK36: a new PET tracer with the synthetic amino acid analogue anti-[18F]FACBC", ANNALS OF NUCLEAR MEDICINE, vol. 25, no. 6, 2011, pages 414 - 418, XP019923740, DOI: 10.1007/s12149-011-0477-z
MARTARELLO, L. ET AL.: "Synthesis of syn- and anti-1-Amino- 3-(18F)fluoromethyl-cyclobutane-1-carboxylic acid (FMACBC), potential PET ligands for tumor detection", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 11, 2002, pages 2250 - 2259, XP002276531, DOI: 10.1021/jm010242p
QI, Y. ET AL.: "Fluorine-18 labeled amino acids for tumor PET/CT imaging", ONCOTARGET, vol. 8, no. 36, 4 August 2017 (2017-08-04), pages 60581 - 60588, XP055679365
BAUM, Y. ET AL.: "Think outside the box: Tackling fluciclovine PET-CT with challenging extraprostatic findings", JOURNAL OF NUCLEAR MEDICINE, vol. 59, no. 1, May 2018 (2018-05-01)
BROSKA, H.: "Prostate Cancer Patients and PET/CT: Comparing and Contrasting 18F-FDG and 18F-Fluciclovine", JOURNAL OF NUCLEAR MEDICINE, vol. 59, no. 1, May 2018 (2018-05-01)
ASANO, Y. ET AL.: "Phase I clinical study of NMK36: a new PET tracer with the synthetic amino acid analogue anti-[18F]FACBC", ANNALS OF NUCLEAR MEDICINE, vol. 25, no. 6, 2011, pages 414 - 418, XP019923740, DOI: 10.1007/s12149-011-0477-z
MARTARELLO, L. ET AL.: "Synthesis of syn- and anti-1-Amino- 3-(18F)fluoromethyl-cyclobutane-1-carboxylic acid (FMACBC), potential PET ligands for tumor detection", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 11, 2002, pages 2250 - 2259, XP002276531, DOI: 10.1021/jm010242p
QI, Y. ET AL.: "Fluorine-18 labeled amino acids for tumor PET/CT imaging", ONCOTARGET, vol. 8, no. 36, 4 August 2017 (2017-08-04), pages 60581 - 60588, XP055679365
BAUM, Y. ET AL.: "Think outside the box: Tackling fluciclovine PET-CT with challenging extraprostatic findings", JOURNAL OF NUCLEAR MEDICINE, vol. 59, no. 1, May 2018 (2018-05-01)
BROSKA, H.: "Prostate Cancer Patients and PET/CT: Comparing and Contrasting 18F-FDG and 18F-Fluciclovine", JOURNAL OF NUCLEAR MEDICINE, vol. 59, no. 1, May 2018 (2018-05-01)
Attorney, Agent or Firm:
IDE Masatake (JP)
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