Title:
LABELLED FACTOR XIIIA SUBSTRATES
Document Type and Number:
WIPO Patent Application WO1998031399
Kind Code:
A3
Abstract:
A complex of a radiometal or paramagnetic metal ion with a metal chelating agent such as a diaminedioxime has attached thereto a substituent of formula (Y)m-A-NHR)k can function as a substrate for the fibrin-stabilizing Factor XIIIa. The complex is useful for the diagnosis or therapy of thrombosis, embolism, atherosclerosis, inflammation or cancer.
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Inventors:
FORSTER ALAN MICHAEL (GB)
KNOX PETER (GB)
MENDIZABAL MARIVI (GB)
RICHARDSON TIMOTHY CHARLES (GB)
STOREY ANTHONY EAMON (GB)
WILSON IAN ANDREW (GB)
CHAMPION SUSAN (GB)
GIBSON ALEX (GB)
GUILBERT BENEDICTE (GB)
KNOX PETER (GB)
MENDIZABAL MARIVI (GB)
RICHARDSON TIMOTHY CHARLES (GB)
STOREY ANTHONY EAMON (GB)
WILSON IAN ANDREW (GB)
CHAMPION SUSAN (GB)
GIBSON ALEX (GB)
GUILBERT BENEDICTE (GB)
Application Number:
PCT/GB1998/000157
Publication Date:
October 22, 1998
Filing Date:
January 19, 1998
Export Citation:
Assignee:
NYCOMED AMERSHAM PLC (GB)
FORSTER ALAN MICHAEL (GB)
KNOX PETER (GB)
MENDIZABAL MARIVI (GB)
RICHARDSON TIMOTHY CHARLES (GB)
STOREY ANTHONY EAMON (GB)
WILSON IAN ANDREW (GB)
CHAMPION SUSAN (GB)
GIBSON ALEX (GB)
GUILBERT BENEDICTE (GB)
FORSTER ALAN MICHAEL (GB)
KNOX PETER (GB)
MENDIZABAL MARIVI (GB)
RICHARDSON TIMOTHY CHARLES (GB)
STOREY ANTHONY EAMON (GB)
WILSON IAN ANDREW (GB)
CHAMPION SUSAN (GB)
GIBSON ALEX (GB)
GUILBERT BENEDICTE (GB)
International Classes:
A61K49/00; A61K51/00; A61K51/04; A61P9/10; A61P31/10; A61P35/00; C07C311/18; C07F13/00; C09K3/00; (IPC1-7): A61K51/04
Domestic Patent References:
| WO1980001685A1 | 1980-08-21 |
Foreign References:
| EP0229718A2 | 1987-07-22 | |||
| EP0544412A2 | 1993-06-02 | |||
| US5387692A | 1995-02-07 |
Other References:
K. RAMALINGAM ET AL.: "SYNTHESIS OF NITROIMIDAZOLE SUBSTITUTED 3,3,9,9-TETRAMETYL-4,8-DIAZAUNDECANE2,10-DIONE DIOXIMES (PNAOS): LIGANDS FOR TECHNETIUM-99M COMPLEXES WITH POTENTIAL FOR IMAGING HYPOXIC TISSUE.", TETRAHEDRON, (INCL TETRAHEDRON REPORTS), vol. 51, no. 10, 1995, OXFORD GB, pages 2875 - 2894, XP002034456
PILLAI, M. R. A. ET AL: "Some observations on the instability of 99mTc-complexes of propyleneamine oxime (PnAO)", NUCL. MED. BIOL. (1994), 21(7), 997-1003 CODEN: NMBIEO;ISSN: 0883-2897, 1994, XP002034457
PILLAI, M. R. A. ET AL: "Some observations on the instability of 99mTc-complexes of propyleneamine oxime (PnAO)", NUCL. MED. BIOL. (1994), 21(7), 997-1003 CODEN: NMBIEO;ISSN: 0883-2897, 1994, XP002034457
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