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Title:
LABYRINTHULID MICROORGANISM CAPABLE OF PRODUCING MICROBIAL OIL, MICROBIAL OIL, METHODS RESPECTIVELY FOR PRODUCING SAID MICROORGANISM AND FOR PRODUCING SAID MICROBIAL OIL, AND USES OF SAID MICROORGANISM AND SAID MICROBIAL OIL
Document Type and Number:
WIPO Patent Application WO/2017/006918
Kind Code:
A1
Abstract:
[Problem] To provide a Labyrinthulid microorganism capable of producing a PUFA only through the elongase-desaturase pathway. [Solution] A Labyrinthulid microorganism which does not have an ability of producing a PUFA through the endogenous PUFA-PKS pathway or has the ability at an extremely weak level and which has an ability of producing a PUFA through the endogenous elongase-desaturase pathway. The Labyrinthulid microorganism is a microorganism belonging to the genus Parietichytrium or Parietichytrium

Inventors:
OKITA YUJI (JP)
ITO MAKOTO (JP)
HAMAGUCHI RIE (JP)
GODA HATSUMI (JP)
MOCHINAGA SEIYA (JP)
HONDA DAISUKE (JP)
Application Number:
PCT/JP2016/069825
Publication Date:
January 12, 2017
Filing Date:
July 04, 2016
Export Citation:
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Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
KONAN GAKUEN (JP)
NIPPON SUISAN KAISHA LTD (JP)
International Classes:
C12P7/64; C12N1/13; C12N15/09; C12P1/00; C12R1/89
Domestic Patent References:
WO2012043826A12012-04-05
WO2011037207A12011-03-31
Other References:
OHARA JUNICHIRO ET AL.: "Two Fatty Acid Elongases Possessing C18-DELTA6/C18-DELTA9/C20-DELTA5 or C16-DELTA9 Elongase Activity in Thraustochytrium sp. ATCC 26185", MAR. BIOTECHNOL., vol. 15, 2013, pages 476 - 486, XP055345968
SAKAGUCHI KEISHI ET AL.: "Versatile Transformation System That Is Applicable to both Multiple Transgene Expression and Gene Targeting for Thraustochytrids", APPL. ENVIRON. MICROBIOL., vol. 78, no. 9, 2012, pages 3193 - 3202, XP055148219
KOBAYASHI TAKUMI ET AL.: "Increase of Eicosapentaenoic Acid in Thraustochytrids through Thraustochytrid Ubiquitin Promoter- Driven Expression of a Fatty Acid DELTA5 Desaturase Gene", APPL. ENVIRON. MICROBIOL., vol. 77, no. 11, 2011, pages 3870 - 3876, XP055150851
MATSUDA TAKANORI ET AL.: "Analysis of DELTA12- fatty acid desaturase function revealed that two distinct pathways are active for the synthesis of PUFAs in T. aureum ATCC 34304", J. LIPID RES., vol. 53, 2012, pages 1210 - 1222,2806, XP055147930
MATSUDA TAKANORI ET AL.: "Molecular cloning of a Pinguiochrysis pyriformis oleate-specific microsomal DELTA12-fatty acid desaturase and functional analysis in yeasts and thraustochytridsy", J. BIOCHEM., vol. 150, no. 4, 2011, pages 375 - 383, XP055345986
LIPPMEIER J. CASEY ET AL.: "Characterization of Both Polyunsaturated Fatty Acid Biosynthetic Pathways in Schizochytrium sp.", LIPIDS, vol. 44, 2009, pages 621 - 630, XP002699319
MATSUDA TAKANORI ET AL.: "Species-dependent pathway for production of PUFA in thraustochytrids revealed by analysis of DELTA12 fatty acid desaturase", CHEMISTRY AND PHYSICS OF LIPIDS, vol. 164, 2011, pages S24, XP055345995
MARTINEZ MANUELA ET AL.: "The DELTA4-desaturation pathway for DHA biosynthesis is operative in the human species: Differences between normal controls and children with the Zellweger syndrome", LIPIDS IN HEALTH AND DISEASE, vol. 9, 2010, pages 98, XP021078169
See also references of EP 3318640A4
Attorney, Agent or Firm:
SUDO, Asako et al. (JP)
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